N-butyl-[1,1′-biphenyl]-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-butyl-[1,1′-biphenyl]-2-amine
• 英文别名: N-(biphenyl)butylamine；N-butyl-2-phenylaniline
• 化学式: C₁₆H₁₉N
• mdl: MFCD11122722
• 分子量: 225.334
• InChiKey: FMJXAYHLEUROOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(2-联苯基)-4-甲基苯磺酰胺 在 三氟甲磺酸 、 potassium carbonate 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 35.0h， 生成 N-butyl-[1,1′-biphenyl]-2-amine
  参考文献：
  名称：

  在酸性条件下磺酰胺的化学选择性脱保护：范围，磺酰基基团迁移和合成应用。

  摘要：

  磺酰胺与三氟甲磺酸的化学选择性酸性水解已被评估为一种脱保护方法，并进一步扩展到更复杂的合成应用中。与常规的麻烦的磺酰胺水解相反，发现接近化学计量的酸足以引起各种中性或电子缺陷的N-芳基磺酰胺的有效脱保护，而富电子的底物提供了磺酰基迁移产物。所开发的脱保护方法对N-芳基磺酰胺具有完全选择性，并且证明了区分各种不同磺酰胺的可能性。

  DOI：

  10.1021/acs.joc.7b02507

文献信息

• Metal-catalyzed amination of organic sulfonates to organic amines
  申请人：Yale University

  公开号：US05817877A1

  公开（公告）日：1998-10-06

  A process of preparing an organic amine having at least one unsaturated group, such as an arylamine, involving contacting an unsaturated organic sulfonate, such as an aryl sulfonate, with a reactant amine, such as an alkyl or aryl amine, in the presence of a base and a transition metal catalyst under reaction conditions. The transition metal catalyst contains a Group 8 metal and a chelating ligand, for example a Group 15-substituted arylene or Group 15-substituted metallocene, such as 1,1'-bis(diphenylphosphino)-2,2'-binaphthyl or 1,1'-bis(diphenylphosphino)-ferrocene, respectively. The aryl sulfonate can be prepared from a phenol and sulfonating agent.

  一种制备具有至少一个不饱和基团的有机胺的过程，例如芳胺，涉及将不饱和有机磺酸酯（例如芳基磺酸酯）与反应胺（例如烷基或芳基胺）在碱和过渡金属催化剂存在下，在反应条件下接触。过渡金属催化剂含有第8族金属和螯合配体，例如第15族取代芳基或第15族取代茂铁，例如1,1'-双(二苯基膦基)-2,2'-联萘基或1,1'-双(二苯基膦基)-二茂铁。芳基磺酸酯可由苯酚和磺化剂制备。
• PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION
  申请人：Saitoh Yuko

  公开号：US20120258063A1

  公开（公告）日：2012-10-11

  An object is to provide an external preparation for skin preferably usable to prevent or ameliorate pigmentation. The object is achieved by providing a preventing or ameliorating agent for pigmentation, consisting of a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof, and an external preparation for skin containing the same as a component: [wherein R 1 represents an unsubstituted aromatic group or an aromatic group having any substituent; R 2 represents a hydrogen atom, a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4, or an acyl group having a linear or branched alkyl chain having a number of carbon atom or atoms of 1 to 4; and R 3 represents a hydrogen atom or a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4.]

  本发明旨在提供一种外用制剂，特别是用于预防或改善色素沉着的皮肤外用制剂。本发明通过提供一种预防或改善色素沉着的制剂，该制剂包括以下一般式（1）所表示的化合物，其异构体和/或药学上可接受的盐，并且包含该化合物作为组分的皮肤外用制剂，从而实现上述目的: [其中R1表示未取代的芳香基或具有任何取代基的芳香基; R2表示氢原子，具有1至4个碳原子的线性链或支链烷基，或具有1至4个碳原子的线性或支链烷基链的酰基; R3表示氢原子或具有1至4个碳原子的线性链或支链烷基。]
• Chemoselective synthesis of tertiary and secondary amines by reductive amination of aldehydes
  作者：Wan-Jin Xiong、Lei Li、Jiang-Tao Li、Shi-Qiang Zhang、Jun-Lei Tang、Taigang Zhou

  DOI：10.1016/j.tetlet.2023.154684

  日期：2023.9

  A simple and efficient catalyst-free chemoselective reductive amination of primary amines and aldehydes to synthesis of tertiary and secondary amines with borane complex was developed. Primary amines are converted into tertiary and secondary amines in one pot reaction under mild condition with good functional group compatibility and It does not require any catalyst to participate in this reaction.

  开发了一种简单高效的无催化剂化学选择性还原胺化伯胺和醛，以与硼烷配合物合成叔胺和仲胺。伯胺转化为叔胺和仲胺的一锅反应条件温和，官能团相容性好，并且不需要任何催化剂参与该反应。通过改变硼烷络合物的空间位阻来实现化学选择性控制。该策略成功应用于合成丁卡因（麻醉剂），并通过同位素标记实验验证了其潜在机制。
• PROPHYLACTIC OR AMELIORATING AGENT FO PIGMENTATION
  申请人：Pola Chemical Industries Inc.

  公开号：EP2514402A1

  公开（公告）日：2012-10-24

  An object is to provide an external preparation for skin preferably usable to prevent or ameliorate pigmentation. The object is achieved by providing a preventing or ameliorating agent for pigmentation, consisting of a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof, and an external preparation for skin containing the same as a component: [wherein R1 represents an unsubstituted aromatic group or an aromatic group having any substituent; R2 represents a hydrogen atom, a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4, or an acyl group having a linear or branched alkyl chain having a number of carbon atom or atoms of 1 to 4; and R3 represents a hydrogen atom or a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4.]

  目的是提供一种可用于预防或改善色素沉着的皮肤外用制剂。为实现上述目标，我们提供了一种色素沉着预防或改善剂，它由以下通式（1）所代表的化合物、其异构体和/或其药理上可接受的盐组成，以及一种以其为成分的皮肤外用制剂： [其中 R1 代表未取代的芳香基团或具有任何取代基的芳香基团；R2 代表氢原子、碳原子数为 1 至 4 的直链或支链烷基或具有碳原子数为 1 至 4 的直链或支链烷基的酰基；R3 代表氢原子或碳原子数为 1 至 4 的直链或支链烷基。］
• US9414998B2
  申请人：——

  公开号：US9414998B2

  公开（公告）日：2016-08-16