benzophenone N-3-chloro-4-fluorophenylhydrazone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzophenone N-3-chloro-4-fluorophenylhydrazone
• 英文别名: N-(benzhydrylideneamino)-3-chloro-4-fluoroaniline
• 化学式: C₁₉H₁₄ClFN₂
• 分子量: 324.785
• InChiKey: VBPOYSWESIYLHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二苯甲酮腙 、 3-氯-4-氟溴苯 在 palladium diacetate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 sodium hydroxide 作用下， 以 2-甲基-2-丁醇 为溶剂， 反应 12.0h， 以83%的产率得到benzophenone N-3-chloro-4-fluorophenylhydrazone
  参考文献：
  名称：

  Method of forming a carbon-heteroatom bond

  摘要：

  本发明涉及一种通过将带有离去基团的不饱和化合物与亲核化合物反应，从而创建碳-杂原子键，尤其是碳-氮键的方法。具体而言，本发明涉及利用芳基化氮有机衍生物的方法创建碳-氮键；创新的方法包括通过将带有离去基团的不饱和化合物与亲核化合物反应，引入一个可以替代离去基团的杂原子，从而在钯基催化剂的存在下创建碳-杂原子键，可选地还包括配体。本发明的特点在于该反应在存在与醇类溶剂相关的有效量的金属羟基或氢氧化铵的情况下进行。

  公开号：

  US07557248B2

文献信息

• Method of Forming a Carbon-Heteroatom Bond
  申请人：Mauger Christelle

  公开号：US20070243999A1

  公开（公告）日：2007-10-18

  The present invention relates to a method of creating a carbon-heteroatom bond, and preferably a carbon-nitrogen bond, by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound. In particular, the invention relates to the creation of a carbon-nitrogen bond, using a method involving the arylation of nitrogenous organic derivatives; the inventive method consists in creating a carbon-heteroatom bond by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound introducing a heteroatom which can be substituted for the leaving group, thereby creating a carbon-heteroatom bond, in the presence of a palladium-based catalyst, optionally a ligand. The invention is characterized in that the reaction takes place in the presence of an effective quantity of a metal hydroxide or ammonium hydroxide which is associated with an alcohol-type solvent.
• US7557248B2
  申请人：——

  公开号：US7557248B2

  公开（公告）日：2009-07-07
• Method of forming a carbon-heteroatom bond
  申请人：Rhodia Chimie

  公开号：US07557248B2

  公开（公告）日：2009-07-07

  The present invention relates to a method of creating a carbon-heteroatom bond, and preferably a carbon-nitrogen bond, by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound. In particular, the invention relates to the creation of a carbon-nitrogen bond, using a method involving the arylation of nitrogenous organic derivatives; the inventive method consists in creating a carbon-heteroatom bond by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound introducing a heteroatom which can be substituted for the leaving group, thereby creating a carbon-heteroatom bond, in the presence of a palladium-based catalyst, optionally a ligand. The invention is characterized in that the reaction takes place in the presence of an effective quantity of a metal hydroxide or ammonium hydroxide which is associated with an alcohol-type solvent.

  本发明涉及一种通过将带有离去基团的不饱和化合物与亲核化合物反应，从而创建碳-杂原子键，尤其是碳-氮键的方法。具体而言，本发明涉及利用芳基化氮有机衍生物的方法创建碳-氮键；创新的方法包括通过将带有离去基团的不饱和化合物与亲核化合物反应，引入一个可以替代离去基团的杂原子，从而在钯基催化剂的存在下创建碳-杂原子键，可选地还包括配体。本发明的特点在于该反应在存在与醇类溶剂相关的有效量的金属羟基或氢氧化铵的情况下进行。