scopolamine hydrobromide trihydrate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: scopolamine hydrobromide trihydrate
• 化学式: (x)BrH*C₁₇H₂₁NO₄*3H₂O
• InChiKey: UXOOBDDSNJVVBU-HXNADDDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.67
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  93.8
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  scopolamine hydrobromide trihydrate 在 zinc/copper couple 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以88%的产率得到6,7-dehydrohyoscyamine
  参考文献：
  名称：

  [EN] FLUOROPHENYL SUBSTITUTED MUSCARINIC RECEPTOR LIGANDS WITH SELECTIVITY FOR M3 OVER M2
  [FR] LIGANDS DES RÉCEPTEURS MUSCARINIQUES À SUBSTITUTION FLUOROPHÉNYLE AYANT UNE SÉLECTIVITÉ POUR M3 SUR M2

  摘要：

  本发明涉及氟苯基取代的毒蕈碱受体配体，其对M3受体的选择性高于M2受体，并涉及这些化合物在治疗哮喘、慢性阻塞性肺病（COPD）、支气管肺发育不良（BPD）和尿失禁等各种疾病中的用途。

  公开号：

  WO2019110521A1

文献信息

• GRANULATED MATERIAL FOR TABLET THAT RAPIDLY DISINTEGRATES IN MOUTH
  申请人：Teika Pharmaceutical Co., Ltd.

  公开号：EP2893940A2

  公开（公告）日：2015-07-15

  The use of a granular material which is for orally fast disintegrating tablets and comprises at least one kind of water soluble polymer and tannic acid allows production of tablets that can be produced by a simple process with simple production equipment, disintegrate fast in the mouth, and have a proper level of moldability for practical use. The at least one kind of water soluble polymer is preferably selected from the group consisting of povidone, hydroxypropyl cellulose, pullulan, a polyvinyl alcohol-polyethylene glycol graft copolymer and copolyvidone.

  使用由至少一种水溶性聚合物和单宁酸组成的用于口服快速崩解片剂的颗粒材料，可以用简单的工艺和简单的生产设备生产片剂，在口中快速崩解，并具有适当的成型性，以满足实际使用的需要。至少一种水溶性聚合物最好选自聚维酮、羟丙基纤维素、拉鲁兰、聚乙烯醇-聚乙二醇接枝共聚物和共聚维酮组成的组。
• COMPOSITION FOR TREATING OR PREVENTING ATOPIC DERMATITIS
  申请人：Nanoegg Research Laboratories, Inc.

  公开号：EP3456353A1

  公开（公告）日：2019-03-20

  The present invention provides a composition and a method both for treating or preventing atopic dermatitis effectively. Provided is a composition which contains an acetylcholine inhibitor, e.g., an anticholinergic substance, as an active ingredient. Also provided is a method which includes a step of administering an acetylcholine inhibitor such as an anticholinergic substance. The detailed mechanism of the development of atopic dermatitis has not been elucidated so far. Therefore, it has been difficult to treat atopic dermatitis effectively. The composition according to the present invention can treat atopic dermatitis effectively through the inhibition of the action of acetylcholine.

  本发明提供了一种有效治疗或预防特应性皮炎的组合物和方法。本发明提供了一种含有乙酰胆碱抑制剂（如抗胆碱能物质）作为活性成分的组合物。还提供了一种方法，其中包括施用乙酰胆碱抑制剂（如抗胆碱能物质）的步骤。迄今为止，特应性皮炎的详细发病机制尚未阐明。因此，特应性皮炎很难得到有效治疗。根据本发明的组合物可以通过抑制乙酰胆碱的作用有效治疗特应性皮炎。
• MEDICINAL COMPOSITION HAVING EXCELLENT ABSORPTION OF DRUG INTO LIVING BODY AND EXCELLENT CHEMICAL STABILITY
  申请人：Nobelpharma Co., Ltd.

  公开号：EP3943156A1

  公开（公告）日：2022-01-26

  A medicinal composition containing a scopolamine salt and/or a hydrate thereof, polyvinylpyrrolidone, and a base. The medicinal composition is excellent in terms of absorption of the drug into the living body and chemical stability thereof.

  一种含有东莨菪碱盐和/或其水合物、聚乙烯吡咯烷酮和基质的药物组合物。该药物组合物在活体吸收药物和化学稳定性方面表现出色。
• EP3838246A1
  申请人：——

  公开号：EP3838246A1

  公开（公告）日：2021-06-23
• GRANULAR MATERIAL FOR ORALLY FAST DISINTEGRATING TABLETS
  申请人：TEIKA PHARMACEUTICAL CO., LTD.

  公开号：US20150238426A1

  公开（公告）日：2015-08-27

  The use of a granular material which is for orally fast disintegrating tablets and comprises at least one kind of water soluble polymer and tannic acid allows production of tablets that can be produced by a simple process with simple production equipment, disintegrate fast in the mouth, and have a proper level of moldability for practical use. The at least one kind of water soluble polymer is preferably selected from, the group consisting of povidone, hydroxypropyl cellulose, pallulan, a polyvinyl alcohol-polyethylene glycol graft copolymer and copolyvidone.