(E)-1-(4-chlorophenyl)pent-3-en-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(4-chlorophenyl)pent-3-en-2-one
• 化学式: C₁₁H₁₁ClO
• 分子量: 194.661
• InChiKey: TVJNNQMEEPDUPJ-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  一氧化碳 、 烯丙基三丁基锡 、 4-氯氯苄 在 bis(acetylacetonato)palladium(II) 、 四正辛基溴化铵 作用下， 以 四氢呋喃 为溶剂， 50.0 ℃ 、500.01 kPa 条件下， 反应 24.0h， 以20%的产率得到(Z)-1-(4-chlorophenyl)pent-3-en-2-one
  参考文献：
  名称：

  Carbonylative Stille coupling reactions of benzyl chlorides with allyltributylstannane catalyzed by palladium nanoparticles

  摘要：

  The carbonylative Stille coupling reaction of benzyl chlorides with allyltributylstannane was successfully conducted by using palladium nanoparticles as the catalyst under phosphine ligand-free conditions. The corresponding alpha,beta-unsaturated ketone products were obtained in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.07.002

文献信息

• Carbonylative Stille coupling reactions of benzyl chlorides with allyltributylstannane catalyzed by palladium nanoparticles
  作者：Jian Sun、Xiujuan Feng、Ziran Zhao、Yoshinori Yamamoto、Ming Bao

  DOI：10.1016/j.tet.2014.07.002

  日期：2014.10

  The carbonylative Stille coupling reaction of benzyl chlorides with allyltributylstannane was successfully conducted by using palladium nanoparticles as the catalyst under phosphine ligand-free conditions. The corresponding alpha,beta-unsaturated ketone products were obtained in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.