methyl 3-methyl-2-cyclohexanone-1-p-methoxyphenyl-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl 3-methyl-2-cyclohexanone-1-p-methoxyphenyl-1-carboxylate
• 英文别名: Methyl 1-(4-methoxyphenyl)-3-methyl-2-oxocyclohexane-1-carboxylate；methyl 1-(4-methoxyphenyl)-3-methyl-2-oxocyclohexane-1-carboxylate
• 化学式: C₁₆H₂₀O₄
• 分子量: 276.332
• InChiKey: RSUZTICZUVQRGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-甲基-2-氧代环己烷羧酸甲酯 、 (4-甲氧苯基)-lambda~2~-铅烷基-乙酸(1:3) 在 吡啶 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以16%的产率得到methyl 3-methyl-2-cyclohexanone-1-p-methoxyphenyl-1-carboxylate
  参考文献：
  名称：

  Diastereoselectivity in the Formation of Quaternary Centers with Aryllead(IV) Tricarboxylates

  摘要：

  [GRAPHICS]The formation of quaternary centers utilizing the reaction of aryllead(IV) tricarboxylates with beta-ketoesters has been investigated, A series of substituted methyl 2-oxo-1-cyclohexanecarboxylates served as substrates for the evaluation of diastereoselectivity in the sp(2)-sp(3) bond forming reaction with p-methoxyphenyllead tricarboxylates. Selectivities ranged from poor to excellent depending on the substituent. A comparison to iodonium salts is discussed.

  DOI：

  10.1021/ol991143x

文献信息

• Diastereoselectivity in the Formation of Quaternary Centers with Aryllead(IV) Tricarboxylates
  作者：Gregory I. Elliott、Joseph P. Konopelski、Marilyn M. Olmstead

  DOI：10.1021/ol991143x

  日期：1999.12.1

  [GRAPHICS]The formation of quaternary centers utilizing the reaction of aryllead(IV) tricarboxylates with beta-ketoesters has been investigated, A series of substituted methyl 2-oxo-1-cyclohexanecarboxylates served as substrates for the evaluation of diastereoselectivity in the sp(2)-sp(3) bond forming reaction with p-methoxyphenyllead tricarboxylates. Selectivities ranged from poor to excellent depending on the substituent. A comparison to iodonium salts is discussed.