((E)-4-氯-3-丁烯)-苯 | 62692-42-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: ((E)-4-氯-3-丁烯)-苯
• 英文名称: (E)-1-chloro-4-phenyl-1-butene
• 英文别名: (E)-(4-chlorobut-3-en-1-yl)benzene；[(E)-4-chlorobut-3-enyl]benzene
• CAS: 62692-42-6
• 化学式: C₁₀H₁₁Cl
• 分子量: 166.65
• InChiKey: UAWVSMAPCUGUAL-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-(4-methoxyphenyl)-3-methylpyrrolidin-2-one 、 ((E)-4-氯-3-丁烯)-苯 在 1,1'-双[(2S,5S)-2,5-二甲基磷杂环戊基]二茂铁 、 lithium hexamethyldisilazane 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 作用下， 以 1,4-二氧六环 为溶剂， 以19%的产率得到
  参考文献：
  名称：

  通过对映选择性 Pd 催化 γ-内酰胺 α-乙烯基化形成全碳四元中心

  摘要：

  在此，我们报道了 α-取代的 γ-内酰胺的对映选择性乙烯基化，形成四元中心，产率高达 59%，ee 为 94%。使用典型的非活性氯乙烯亲电子试剂可提供最高的产率和立体选择性水平，并且发现一系列三取代氯乙烯能够有效促进这种转化。这些立体产物可以进一步加工成功能丰富的支架，从而突出该过程的合成效用。

  DOI：

  10.1021/acs.orglett.4c02551
• 作为产物：
  描述：

  1-氯-4-苯基丁烷 生成 ((E)-4-氯-3-丁烯)-苯
  参考文献：
  名称：

  ABDEL-WAHAB, ABOEL-MAGD, A.;ISMAIL, MOHAMED, T.;MOHAMED, OMAIMA, S.;KHALA+, GAZZ. CHIM. ITAL., 1985, 115, N 11-12, 591-594

  摘要：

  DOI：

文献信息

• New Highly Nucleophilic and Practically Accessible Chlorocarbenoids for Carbonyl Olefination
  作者：Chia-Chung Tsai、Ching-Ting Chien、Yu-Cheng Chang、Huan-Chang Lin、Tu-Hsin Yan

  DOI：10.1021/jo050455c

  日期：2005.7.1

  bimetallic species resulted in the generation of a highly nucleophilic and practically convenient chloromethylenetitanium complex, which efficiently effected condensation even with enolizable or inert carbonyl compounds, such as sterically congested ketones, to provide vinyl chloride compounds.

  将CHCl 3直接氧化添加到Mg-TiCl 4双金属物质中，导致生成高度亲核且实用的氯亚甲基钛配合物，即使与可烯化或惰性的羰基化合物（例如空间拥挤的酮）也能有效地进行缩合，从而提供氯乙烯化合物。
• A convenient preparation of (or ) -1-chloroalkenes from (or )-1,2-dichloroethylene: A new synthesis of the sex pheromone of lobesia botrana.
  作者：Victorin Ratovelomanana、Gérard Linstrumelle

  DOI：10.1016/0040-4039(81)80085-8

  日期：1981.1

  (or ) -dichloroethylene leads to (or )-1-chloroalkenes when treated with Grignard reagents and to (or )-1-chloro-1-en-3-ynes when treated with terminal acetylenes. A simple synthesis of (7E, 9Z)-dodecadien-1-yl acetate has been realized.

  （或）-dichloroethylene导致（或）-1-氯烯烃当与格氏试剂和治疗（或）-1-氯-1-烯-3-炔当与终端炔处理。已经实现了乙酸（7E，9Z）-十二碳烯-1-基酯的简单合成。
• SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF
  申请人：Myers Andrew G.

  公开号：US20110166170A1

  公开（公告）日：2011-07-07

  The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.

  本文介绍了自然产物avrainvillamide和stephacidin B的合成方法。其中，avrainvillamide的α,β-不饱和亚硝基功能团和其3-烷基亚甲基-3H-吲哚1-氧化物核心被证明能够与杂原子型亲核试剂共价、可逆结合。这种能力可能使这些分子能够结合活性位点的亲核试剂，并为设计有效且选择性的酶抑制剂提供基础。avrainvillamide和其二聚体stephacidin B均已被报道具有抗增殖活性，而avrainvillamide还被报道对多重耐药菌具有抗菌活性。研究发现，avrainvillamide能够靶向细胞骨架连接膜蛋白（CLIMP-63），从而防止细胞进行有丝分裂。本发明提供了这些天然产物以及它们的类似物和功能核心的合成方法。这些化合物可以用于治疗癌症、自身免疫性疾病和细菌感染等疾病。
• RESPONSIVE MICROGEL AND METHODS RELATED THERETO
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP1478403A1

  公开（公告）日：2004-11-24
• [EN] RESPONSIVE MICROGEL AND METHODS RELATED THERETO<br/>[FR] MICROGEL SENSIBLE ET SES PROCEDES ASSOCIES
  申请人：SUPRATEK PHARMA INC

  公开号：WO2003063909A1

  公开（公告）日：2003-08-07

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of 'dangling chains' and wherein the 'dangling chains' of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substanially linear and sustained release of the therapeutic entity under physiological conditions.