(1-(苄氧基)乙烯基)苯 | 25109-98-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (1-(苄氧基)乙烯基)苯
• 英文名称: α-(benzyloxy)styrene
• 英文别名: (1-(benzyloxy)vinyl)benzene；1-benzyloxy-1-phenylethene；α-benzyloxystyrene；1-benzoxy-1-phenylethene；α-Benzyloxy-styrol；α-Benzyloxystyrol；1-Phenylethenoxymethylbenzene
• CAS: 25109-98-2
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: BIRJAUKLRAMLEV-UHFFFAOYSA-N

物化性质

• 沸点：
  338.5±31.0 °C(Predicted)
• 密度：
  1.039±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1-(苄氧基)乙烯基)苯 在 偶氮二异丁腈 作用下， 以 苯 为溶剂， 以40%的产率得到ω-苄基苯乙酮
  参考文献：
  名称：

  Carboncarbon bond formation by radical addition–fragmentation reactions of O-tert-alkyl enols and O-cyclopropylcarbinyl enols

  摘要：

  Terminal alkenes of the type H(2)C=C(OR(1))X, in which R(1) is a tertiary alkyl or a 1-cyclopropylethyl group and X=Ph, OSiMe(2)Bu', OEt or H, undergo radical-chain reactions with organic halides R(2)Hal to give carbonyl compounds R(2)CH(2)C(=O)X. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01092-x
• 作为产物：
  描述：

  (2-(benzyloxy)-2-phenylethyl)(phenyl)selane 在 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 生成 (1-(苄氧基)乙烯基)苯
  参考文献：
  名称：

  从苯基 2-羟基烷基硒化物方便的一锅法合成乙烯基醚

  摘要：

  摘要 通过苯基 2-羟烷基硒化物与伯或仲有机卤化物的 O-烷基化反应，然后用 30% 的过氧化氢氧化消除，在一锅两步转化中以良好的收率制备了乙烯基醚。

  DOI：

  10.1080/00397910500296901

文献信息

• Dynamic Kinetic Asymmetric [3 + 2] Annulation Reactions of Aminocyclopropanes
  作者：Florian de Nanteuil、Eloisa Serrano、Daniele Perrotta、Jerome Waser

  DOI：10.1021/ja5024578

  日期：2014.4.30

  asymmetric [3 + 2] annulation reaction of aminocyclopropanes with both enol ethers and aldehydes. Using a Cu catalyst and a commercially available bisoxazoline ligand, cyclopentyl- and tetrahydrofurylamines were obtained in 69-99% yield and up to a 98:2 enantiomeric ratio using the same reaction conditions. The method gives access to important enantio-enriched nitrogen building blocks for the synthesis of bioactive

  我们报告了氨基环丙烷与烯醇醚和醛的动态动力学不对称 [3 + 2] 环化反应的第一个例子。使用铜催化剂和市售的双恶唑啉配体，使用相同的反应条件，以 69-99% 的产率和高达 98:2 的对映体比获得环戊基胺和四氢呋喃胺。该方法提供了用于合成生物活性化合物的重要的富含对映体的氮结构单元。
• Compound embodiments that release H2S by reaction with a reactive compound and methods of making and using the same
  申请人：University of Oregon

  公开号：US11078157B1

  公开（公告）日：2021-08-03

  Disclosed herein are embodiments of a donor compound that releases H2S by reacting with a reactive compound. The donor compound embodiments described herein can be used to deliver H2S to a subject or a sample and further can be used to administer therapeutic agents. The donor compound embodiments also can facilitate bioconjugation. Methods of making and using the donor compound embodiments also are disclosed.

  本文揭示了一种供体化合物的实施例，通过与反应性化合物发生反应释放H2S。本文描述的供体化合物实施例可用于向受试者或样品释放H2S，并且进一步可用于给药治疗剂。供体化合物实施例还可以促进生物共轭。还公开了制备和使用供体化合物实施例的方法。
• Selective Approaches to α‐ and β‐Arylated Vinyl Ethers
  作者：Anna Domzalska‐Pieczykolan、Ignacio Funes‐Ardoiz、Bartłomiej Furman、Carsten Bolm

  DOI：10.1002/anie.202109801

  日期：2022.1.3

  Benzyl vinyl ethers have selectively been arylated at either α or β position by fine-tuned Heck-type palladium catalyses. In contrast to previous protocols, no excess of arylating reagent or substrate chelation is necessary. For achieving good yields and high α/β-selectivities various factors determining the catalytic system had to be optimized. The results of DFT computational studies correlate selectivity

  苄基乙烯基醚已通过微调的 Heck 型钯催化剂在 α 或 β 位选择性芳基化。与以前的协议相比，不需要过量的芳基化试剂或底物螯合。为了获得良好的收率和高 α/β-选择性，必须优化决定催化体系的各种因素。DFT 计算研究的结果将选择性与 Pd 中心上的电子丰富度相关联。
• Petasis Olefination in a Continuous-Flow Microwave Reactor: exo-Glycals from Sugar Lactones
  作者：Horst Kunz、Stefan Koch、Holger Löwe

  DOI：10.1055/s-0030-1261163

  日期：2011.9

  An efficient Petasis olefination of sugar lactones under continuous-flow microwave conditions was developed. Their conversion into exo-glycals can be steered by adjusting the residence time and the concentration of the solution within the reactor. Applying a continuous-flow procedure, the reaction time can be shortened to less than three minutes, several hundred times shorter compared to values given in the literature for batch procedures. This setup is utilizable for a gram-scale synthesis of enol ethers and exo-glycals, in particular, such ones containing potentially (Lewis) acid sensitive acetalic protecting groups.

  在连续流动微波条件下，开发了糖内酯的高效Petasis烯化反应。通过调整反应器内溶液的停留时间和浓度，可以控制其转化为外向糖苷。采用连续流动工艺，反应时间可以缩短到3分钟以内，比文献中给出的间歇工艺值缩短了几百倍。这种装置可用于克级烯醇醚和外向糖苷的合成，特别是那些含有潜在（路易斯）酸敏感的乙缩醛保护基团的烯醇醚和外向糖苷。
• NOVEL CHAIN TRANSFER AGENTS
  申请人：——

  公开号：US20020016424A1

  公开（公告）日：2002-02-07

  A method for making a polymer comprising the step of synthesizing a polymer by employing a chain transfer agent having the formula (II) 1 where X and Y are independently selected from oxygen, sulfur, and fully-substituted nitrogen where R 1 and R 2 are independently selected from hydrogen, halogen, or an organic group, with the proviso that at least one of R 1 or R 2 be hydrogen or halogen, R 3 is an organic group, R 4 and R 5 are independently selected organic groups.

  一种制备聚合物的方法，包括通过采用具有式（II）的链转移剂合成聚合物的步骤，其中X和Y分别从氧、硫和全取代氮中独立选择，其中R1和R2分别从氢、卤素或有机基团中独立选择，但至少有一个R1或R2是氢或卤素，R3是有机基团，R4和R5是独立选择的有机基团。