(1S,2r)-(+)-2-氨基环庚烷羧酸 | 755749-93-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (1S,2r)-(+)-2-氨基环庚烷羧酸
• 英文名称: (+/-)-cis-2-aminocycloheptanecarboxylic acid
• 英文别名: cis-2-Aminocycloheptanecarboxylic acid；(1S,2R)-2-azaniumylcycloheptane-1-carboxylate
• CAS: 755749-93-0
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: QKYSUVFRBTZYIQ-NKWVEPMBSA-N

物化性质

• 沸点：
  296.0±33.0 °C(Predicted)
• 密度：
  1.091±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S,2r)-(+)-2-氨基环庚烷羧酸 在 氯化亚砜 、 Candida antarctica Lipase A 作用下， 以 异丙醚 为溶剂， 反应 4.8h， 生成 methyl (1R,2S)-2-aminocycloheptanecarboxylate hydrochloride
  参考文献：
  名称：

  Lipase-catalyzed kinetic resolution of 7-, 8- and 12-membered alicyclic β-amino esters and N-hydroxymethyl-β-lactam enantiomers

  摘要：

  Enzymatic kinetic resolutions of methyl cis-2-aminocycloheptane-, 2-aminocyclooctane- and 2-aminocyclododecanecarboxylates with Candida antarctica lipase A in diisopropyl ether (E > 200) and of the corresponding N-hydroxymethyl-beta-lactams with Pseudomonas cepacia lipase in dry acetone (E from 27 to > 200) has been performed with 2,2,2-trifluoroethyl butanoate as the best acyl donor, with both enantiomers being obtained. trans-13-Hydroxymethyl-13-azabicyclo[10.2.0]tetradecan-14-one was resolved with vinyl butanoate and Candida antarctica lipase B (E=26) in acetone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2003.08.028

文献信息

• 2,4-diamino-pyrimidines as aurora inhibitors
  申请人：Zahn Karl Stephan

  公开号：US20070032514A1

  公开（公告）日：2007-02-08

  The present invention encompasses compounds of general formula (1) wherein R 1 to R 3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

  本发明涵盖了一般式（1）的化合物 其中 R 1 至 R 3 如权利要求书中所定义，适用于治疗以细胞过度或异常增殖为特征的疾病，并用于制备具有上述特性的药物组合物。
• Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives
  申请人：Marcin R. Lawrence

  公开号：US20050113442A1

  公开（公告）日：2005-05-26

  A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extracellular deposition of β-amyloid. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.

  本文描述了一系列N-环烷基羧酰胺衍生物的N-苯甲基苯磺酰胺化合物，其化学式为I。这些化合物抑制β-淀粉样肽（β-AP）的产生，可用于治疗阿尔茨海默病和其他由β-淀粉样蛋白异常细胞外沉积所特征的疾病。还公开了使用这些化合物的药物组合物和治疗方法。
• 2,4-DIAMINO-PYRIMIDINES AS AURORA INHIBITORS
  申请人：ZAHN Stephan Karl

  公开号：US20110251174A1

  公开（公告）日：2011-10-13

  The present invention encompasses compounds of general formula (1) wherein R 1 to R 3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

  本发明涵盖了通式（1）中定义的化合物，其中R1到R3如权利要求1所定义，适用于治疗以细胞过度或异常增殖为特征的疾病，并且用于制备具有上述特性的制药组合物。
• Therapeutic peptides
  申请人：COHBAR, INC.

  公开号：US11111271B2

  公开（公告）日：2021-09-07

  Provided herein are peptides and peptide analogs and methods of treating a metabolic disease, e.g., obesity, diabetes, methods of treating cancer, methods of treating a liver disease, and methods of modulating fatty acid metabolism.

  本文提供了肽和肽类似物以及治疗代谢性疾病的方法，例如肥胖症、糖尿病、治疗癌症的方法、治疗肝病的方法以及调节脂肪酸代谢的方法。
• Peptide inhibitors of transcription factor aggregation
  申请人：ADRX, INC.

  公开号：US11117930B2

  公开（公告）日：2021-09-14

  This invention relates to materials, such as peptides, and methods to inhibit the aggregation transcription factors, for example p53 inhibitors, p63 inhibitors and p73 inhibitors. More specifically, the invention relates to cancer chemotherapeutics. More specifically, the invention provides pharmaceutical compositions and methods of treating cancer with certain peptides.

  本发明涉及抑制转录因子（例如 p53 抑制剂、p63 抑制剂和 p73 抑制剂）聚集的材料（例如肽）和方法。更具体地说，本发明涉及癌症化疗药物。更具体地说，本发明提供了用某些肽治疗癌症的药物组合物和方法。