尼噻吖 | 139-94-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 尼噻吖
• 中文别名: 1-乙基-3-(5-硝基噻唑-2-基)脲；硝乙脲噻唑
• 英文名称: 1-ethyl-3-(5-nitro-thiazol-2-yl)-urea
• 英文别名: N-ethyl-N'-(5-nitro-thiazol-2-yl)-urea；N-Aethyl-N'-(5-nitro-thiazol-2-yl)-harnstoff；1-Ethyl-3-(5-nitro-2-thiazolyl)harnstoff；Nithiazide；1-ethyl-3-(5-nitro-1,3-thiazol-2-yl)urea
• CAS: 139-94-6
• 化学式: C₆H₈N₄O₃S
• 分子量: 216.221
• InChiKey: FQSUTLQHSDLLAN-UHFFFAOYSA-N

物化性质

• 熔点：
  228°C (rough estimate)
• 密度：
  1.478 (estimate)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• 物理描述：
  Crystals or brown powder. (NTP, 1992)
• 颜色/状态：
  Crystals
• 分解：
  When heated to decomposition it emits very toxic fumes of /nitrogen oxides/ and /phosphorus oxides/.
• 解离常数：
  pKa = 7.3

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  5

ADMET

毒理性

• 致癌性证据

致癌性分类：1）人类证据：无数据；2）动物证据：有限。对人类致癌风险的总体评估为第3组：该物质对人类致癌性不可分类。/来自表格/

Classification of carcinogenicity: 1) evidence in humans: no data; 2) evidence in animals: limited. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. /From table/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌物：硝基噻唑烷

IARC Carcinogenic Agent:Nithiazide

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构（IARC）致癌物分类：第3组：无法归类其对人类致癌性

IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构专著：第31卷：（1983年）某些食品添加剂、饲料添加剂和天然存在物质

IARC Monographs:Volume 31: (1983) Some Food Additives, Feed Additives and Naturally Occurring Substances

来源:International Agency for Research on Cancer (IARC)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……监测休克，如有必要，进行治疗……预计可能出现癫痫，如有必要，进行治疗……对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于摄入，如果患者能够吞咽，有强烈的干呕反射，并且不流口水，用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……在去污后，用干无菌敷料覆盖皮肤烧伤……/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2934100090

反应信息

• 作为反应物：
  描述：

  2-氯-N-甲基乙酰胺 、 尼噻吖 生成 N-ethylcarbamoyl-N-(5-nitro-thiazol-2-yl)-glycine methylamide
  参考文献：
  名称：

  抗寄生虫5-硝基噻唑和5-硝基-4-噻唑啉。4。

  摘要：

  DOI：

  10.1021/jm00248a014

文献信息

• [EN] METHOD OF CONVERTING CARBON DIOXIDE INTO CARBONYL COMPOUNDS<br/>[FR] PROCÉDÉ DE CONVERSION DE DIOXYDE DE CARBONE EN COMPOSÉS CARBONYLE
  申请人：TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE

  公开号：WO2019073484A1

  公开（公告）日：2019-04-18

  The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by Figure 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from -40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from -40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

  本发明提供了一种固定二氧化碳气体的方法，所述方法将二氧化碳气体固定为由图1所示的化学式（3）代表的羰基化合物，包括在溶液中驱除碳酸气体，所述溶液中包含由化学式（1）代表的亲核试剂，在溶剂存在下，在温度范围从-40摄氏度到35摄氏度进行，然后在温度范围从-40摄氏度到35摄氏度添加试剂，然后添加由化学式（2）代表的另一个亲核试剂，以获得由化学式（3）代表的羰基化合物。本发明可优势用于获得商业重要的羰基化合物，并清除大气和工业废水中的不需要的二氧化碳气体。
• Inhibitors of cellular necrosis
  申请人：Cuny D. Gregory

  公开号：US20050119260A1

  公开（公告）日：2005-06-02

  The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.

  本发明涉及化合物、药物制剂及其在预防或治疗与细胞死亡相关的创伤、缺血、中风和退行性疾病中的应用的治疗。本发明的方法和组合物特别适用于治疗与细胞坏死相关的神经系统疾病。
• INHIBITORS OF CELLULAR NECROSIS
  申请人：Cuny Gregory D.

  公开号：US20120149702A1

  公开（公告）日：2012-06-14

  The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.

  本发明涉及化合物和药物制剂及其在预防或治疗与细胞死亡相关的创伤、缺血、中风和退行性疾病中的应用。本发明的方法和组合物特别适用于治疗与细胞坏死相关的神经系统疾病。
• Nucleic acids for the prevention and treatment of sexually transmitted diseases
  申请人：——

  公开号：US20020091097A1

  公开（公告）日：2002-07-11

  The invention relates to methods and products for preventing and/or treating sexually transmitted diseases. A nucleic acid and optionally an anti-STD agent, a birth control agent and/or a birth control device are administered, optionally in the context of a sustained release device to a subject to prevent or treat STD.

  本发明涉及预防和/或治疗性传播疾病的方法和产品。 可选择在持续释放装置中向受试者施用核酸和抗性传播疾病药剂、节育药剂和/或节育装置，以预防或治疗性传播疾病。
• Methods to selectively inactivate parasites in biological compositions
  申请人：V. I. Technologies, Inc.

  公开号：US20040053208A1

  公开（公告）日：2004-03-18

  The invention features a method for inactivating parasites in biological compositions. The method includes contacting the biological composition with an aziridino compound under parasite inactivating conditions.

  本发明的特点是一种灭活生物组合物中寄生虫的方法。该方法包括在寄生虫失活条件下将生物组合物与氮丙啶化合物接触。