(2-己基苯基)甲醇 | 3351-71-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: (2-己基苯基)甲醇
• 英文名称: (2-(hexyloxy)phenyl)methanol
• 英文别名: [2-(hexyloxy)phenyl]methanol；o-Hexyloxy-benzylalkohol；(2-hexoxyphenyl)methanol
• CAS: 3351-71-1
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: BAYXSRGRDHBQOR-UHFFFAOYSA-N

物化性质

• 沸点：
  316.0±17.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-己基苯基)甲醇 在 p-CO₂H-IBX 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以94%的产率得到2-正己氧基苯甲醛
  参考文献：
  名称：

  Expedient synthesis and solvent dependent oxidation behavior of a water-soluble IBX derivative

  摘要：

  IBX derivative 6, synthesized in two steps from 2-aminoterephthalic acid, 8, is soluble in both DMF and water. A variety of alcohols are oxidized using 6 in DMF with ease and selectivity identical to that of parent IBX. However, oxidations carried out in water and other aqueous solvent mixtures using 6 exhibit unique selectivities toward different substrates and provide products different from reactions carried out in DMF. A mechanistic rationale is provided for this solvent dependent behavior of 6. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2008.05.017
• 作为产物：
  描述：

  2-正己氧基苯甲醛 在 lithium aluminium tetrahydride 作用下， 生成 (2-己基苯基)甲醇
  参考文献：
  名称：

  337.氨基氧基衍生物。第五部分.2-取代的4,6-二氨基-1,2-二氢-1-羟基-1,3,5-三嗪的一些O-醚

  摘要：

  DOI：

  10.1039/jr9650001829

文献信息

• CARBAZOLE COMPOUND HAVING ANTI-VIRUS ACTIVITY
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20180057527A1

  公开（公告）日：2018-03-01

  The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of consisting of a carbazole compound which shows excellent anti-proliferative efficacy against hepatitis C virus (HCV), a pharmaceutically acceptable salt thereof, a hydrate thereof, and an isomer thereof; an anti-virus pharmaceutical composition including the novel compound as an active ingredient; a pharmaceutical composition for preventing or treating liver diseases caused by hepatitis C virus; and a method of preparing the novel compound.

  本发明涉及一种具有抗病毒活性的咔唑化合物，更具体地说，涉及一种从咔唑化合物组中选择的新化合物，该化合物对丙型肝炎病毒（HCV）表现出优异的抗增殖功效，其药用盐、水合物和异构体；包括该新化合物作为活性成分的抗病毒药物组合物；用于预防或治疗由丙型肝炎病毒引起的肝病的药物组合物；以及制备该新化合物的方法。
• Novel dicarboxylic acid derivatives with pharmaceutical properties
  申请人：Alonso-Alija Cristina

  公开号：US20080058314A1

  公开（公告）日：2008-03-06

  The present invention relates to the use of compounds of the formula (I) and to their salts and stereoisomers, for the preparation of medicaments for the treatment of cardiovascular disorders.

  本发明涉及使用式(I)的化合物及其盐和立体异构体，用于制备治疗心血管疾病的药物。
• AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY
  申请人：WELLSTAT THERAPEUTICS CORPORATION

  公开号：US20150361077A1

  公开（公告）日：2015-12-17

  Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

  本文描述了对炎症、真菌、单细胞寄生微生物和癌症具有活性的胺化合物。这些化合物包含一个单环、双环或三环芳香环，其中含有一个、两个或三个环氮原子。
• Optcally active compounds
  申请人：SANYO CHEMICAL INDUSTRIES LTD.

  公开号：EP0385692A2

  公开（公告）日：1990-09-05

  Optically active compounds represented by the following formula (1), (2) or (3) are disclosed. wherein R and R are C1-20 alkyl groups; X and Y1 are -, O, S, or divalent groups such as COO, OOC and OCOO; m is 0 or 1; n is 0 to 5; A2 is a cyclic group, such as p,p'-biphenylene, 2,6-naphthylene, 2,5-pyrimidinylene-1,4-phenylene, A1-Y2-pyridylene or A4-Y2-A5; Y2 is CH2CH2 or C-C triple bond; A3 is 2,6-naphthylene, A1-Y2-pyridylene or A6-CH2CH2-A7; A1, A4, As, A6 and A7 are cyclic groups, such as 1,4-phenylene and/or 4,4 -biphenylene.

  本发明公开了下式（1）、（2）或（3）所代表的光学活性化合物。 其中 R 和 R 是 C1-20 烷基；X 和 Y1 是-、O、S 或二价基团，如 COO、OOC 和 OCOO；m 是 0 或 1；n 是 0 至 5；A2 是环状基团，如 p,p'-联苯、2,6-萘、2,5-嘧啶-1,4-亚苯基、A1-Y2-吡啶或 A4-Y2-A5；Y2 是 CH2CH2 或 C-C 三键；A3 是 2，6-萘、A1-Y2-吡啶或 A6-CH2CH2-A7；A1、A4、As、A6 和 A7 是环状基团，如 1，4-亚苯基和/或 4，4-联苯。
• Amine compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity
  申请人：Wellstat Therapeutics Corporation

  公开号：US10030015B2

  公开（公告）日：2018-07-24

  Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

  本文描述了具有抗炎、抗真菌、抗单细胞寄生微生物和抗癌活性的胺化合物。这些化合物含有单环、双环或三环芳香环，环上有一个、两个或三个氮原子。