(2-氯苯基)(2,2,2-三氯乙基)氯磷酸 | 59819-52-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2-氯苯基)(2,2,2-三氯乙基)氯磷酸
• 中文别名: 2-氯苯基 2,2,2-三氯乙基氯磷酸酯
• 英文名称: 2,2,2-trichloroethyl 2-chlorophenyl phosphorochloridate
• 英文别名: 2-Chlorophenyl 2,2,2-trichloroethyl chlorophosphate；1-chloro-2-[chloro(2,2,2-trichloroethoxy)phosphoryl]oxybenzene
• CAS: 59819-52-2
• 化学式: C₈H₆Cl₅O₃P
• 分子量: 358.373
• InChiKey: ORLCYMQZIPSODD-UHFFFAOYSA-N

物化性质

• 沸点：
  366.7±52.0 °C(Predicted)
• 密度：
  1.574 g/mL at 20 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  6.1(a)
• 危险类别码：
  R14,R34
• 危险品运输编号：
  UN 3265 8/PG 2
• 包装等级：
  II
• 危险类别：
  6.1(a)
• 安全说明：
  S26,S36/37/39,S45

反应信息

• 作为反应物：
  描述：

  (2-氯苯基)(2,2,2-三氯乙基)氯磷酸 在 N-甲基咪唑 、 2,4,6-triisopropylbenzenesulfonic acid 、 锌 作用下， 以 吡啶 、 乙腈 为溶剂， 反应 0.8h， 生成 Phosphoric acid (2R,3R,4R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-2-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester
  参考文献：
  名称：

  Chemical synthesis of pppA2'p5'A2'p5'A, an interferon-induced inhibitor of protein synthesis, and some functional analogs

  摘要：

  DOI：

  10.1021/jo00324a010

文献信息

• Nucleotide, XVIII. Synthese und Eigenschaften von (tert-Butyldimethylsilyl)guanosinen, Guanosin-3?-phosphotriestern und Guanosin-haltigen Oligoncleotiden
  作者：Dieter Flockerzi、Wilhelm Schlosser、Wolfgang Pfleiderer

  DOI：10.1002/hlca.19830660718

  日期：1983.11.2

  Nucleotides, XVIII. Synthesis and Properties of (tert-Butyldimethylsilyl)guanosines, Guanosine-3′-Phosphotriesters and Guanosine-containing Oligonucleotides

  核苷酸，十八。（叔丁基二甲基甲硅烷基）鸟苷，鸟苷-3'-磷酸三酯和含鸟苷的寡核苷酸的合成及性能
• Treatment or prophylaxis of diseases caused by pilus-forming bacteria
  申请人：——

  公开号：US20030198992A1

  公开（公告）日：2003-10-23

  Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

  本发明揭示了治疗和/或预防由组织粘附细菌引起的疾病的新方法。通过与周质分子伴侣相互作用，防止或抑制鞭毛的组装，从而减少细菌的感染性。此外，还揭示了筛选药物的方法以及设计这种药物的新方法，这些方法依赖于涉及大分子之间结合自由能的近似计算的新型计算机药物建模方法。最后，还揭示了新型吡喃糖苷，据信能够与周质分子伴侣相互作用。
• Flame retardant, additive compositions, and flame retardant polyurethanes
  申请人：Hussain Saadat

  公开号：US20050113495A1

  公开（公告）日：2005-05-26

  Provided are new flame retardants and liquid flame retardant additive compositions of low viscosity for use in flexible polyurethane foams. The new flame retardants are the reaction product of at least one brominated aromatic diester diol with at least one alcohol-reactive agent. Preferred liquid flame retardant additive compositions are capable of minimizing visible scorching of the foam during its production. Flexible flame retardant polyurethane foams and methods for their production are also provided. The flame retardant additive compositions are formed at least from a) at least one reaction product of a brominated aromatic diester diol and an alcohol-reactive agent; b) at least one hindered amine antioxidant; and c) at least one phenolic antioxidant in which the phenolic ring is substituted by an alkanoic acid alkyl ester group in which alkanoic acid moiety has in the range of 2 to about 4 carbon atoms and the alkyl group has in the range of about 6 to about 16 carbon atoms.

  本文提供了用于软质聚氨酯泡沫的新型阻燃剂和低粘度液体阻燃添加剂组合物。新型阻燃剂是至少一种溴化芳香族二酯二醇与至少一种醇反应剂的反应产物。优选的液态阻燃添加剂组合物能够在泡沫生产过程中最大限度地减少可见的焦烧现象。此外，还提供了柔性阻燃聚氨酯泡沫及其生产方法。阻燃添加剂组合物至少由以下物质形成：a) 至少一种溴化芳香族二酯二元醇与醇反应剂的反应产物；b) 至少一种受阻胺抗氧化剂；c) 至少一种酚类抗氧化剂，其中酚环被烷酸烷基酯基团取代，烷酸分子的碳原子数在 2 至约 4 之间，烷基的碳原子数在约 6 至约 16 之间。
• Phosphorylation of nucleosides using molecular sieves as acid scavengers
  作者：V. Kohli、H. Blöcker、H. Köster

  DOI：10.1016/s0040-4039(01)85538-6

  日期：1980.1
• Lammers,J.G.; van Boom,J.H., Recueil des Travaux Chimiques des Pays-Bas, 1979, vol. 98, p. 243 - 250
  作者：Lammers,J.G.、van Boom,J.H.

  DOI：——

  日期：——