(S)-2,3-bis-hexadec-9c-enoyloxy-propan-1-ol | 127994-00-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (S)-2,3-bis-hexadec-9c-enoyloxy-propan-1-ol
• 英文别名: 1,2-di-(9Z-hexadecenoyl)-sn-glycerol；[(2S)-2-[(Z)-hexadec-9-enoyl]oxy-3-hydroxypropyl] (Z)-hexadec-9-enoate
• CAS: 127994-00-7
• 化学式: C₃₅H₆₄O₅
• 分子量: 564.89
• InChiKey: HSQHRRHRYJNSOC-DWCRPSDDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.2
• 重原子数：
  40
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-2,3-bis-hexadec-9c-enoyloxy-propan-1-ol 、 Cytidindiphosphatcholin 生成 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine 、 cytidine 5'-monophosphate 、 氢(+1)阳离子
  参考文献：
  名称：

  Henneberry A.L.; McMaster C.R., Biochem J, 1999, 0264-6021, 291-8

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lecithinase-substance 作用下， 生成 (S)-2,3-bis-hexadec-9c-enoyloxy-propan-1-ol
  参考文献：
  名称：

  The Action of Lecithinase D on Lecithin. The Enzymatic Preparation of D-1,2-Dipalmitolein and D-1,2-Dipalmitin¹

  摘要：

  DOI：

  10.1021/ja01636a021

文献信息

• METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND FOR THE TREATMENT OF ADRENOLEUKODYSTROPHY
  申请人：Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)

  公开号：EP3118621A1

  公开（公告）日：2017-01-18

  The present invention is directed to a diagnostic method for adrenoleukodystrophy in a subject based on the determination of the levels of different markers. The invention also provides a method for monitoring the progression of an adrenoleukodystrophy, a method for monitoring the effect of an adrenoleukodystrophy therapy and fingolimod, an analogue, metabolite or derivative thereof, or a pharmaceutically acceptable salt thereof, for use in the treatment and/or prevention of an adrenoleukodystrophy.

  本发明涉及一种基于不同标记物水平测定的受试者肾上腺脑白质营养不良症的诊断方法。本发明还提供了一种监测肾上腺白质营养不良症进展的方法、一种监测肾上腺白质营养不良症治疗效果的方法以及用于治疗和/或预防肾上腺白质营养不良症的芬戈莫德、其类似物、代谢物或衍生物或其药学上可接受的盐。
• Controlling translocation through nanopores with fluid walls
  申请人：The Regents of the University of Michigan

  公开号：US10254271B2

  公开（公告）日：2019-04-09

  Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.

  如果在根据库尔特原理运行的设备中，连接液体隔间的纳米孔具有流体涂层（如脂质壁），则可提高纳米粒子的分辨率和检测能力。流体脂质壁由脂质双分子层构成，最好包括脂质锚定移动配体作为脂质双分子层的一部分。通过改变脂质双分子层中可移动配体的性质和浓度，可提供多功能的脂质涂层。
• POLYPEPTIDES OF PSEUDOMONAS AERUGINOSA
  申请人：Shire BioChem Inc.

  公开号：EP1458752A2

  公开（公告）日：2004-09-22
• COMPOSITIONS AND METHODS FOR ENHANCING CONTRAST IN IMAGING
  申请人：Marval Biosciences, Inc.

  公开号：EP2410990A1

  公开（公告）日：2012-02-01
• CONTROLLING TRANSLOCATION THROUGH NANOPORES WITH FLUID WALL
  申请人：Mayer Michael

  公开号：US20130048499A1

  公开（公告）日：2013-02-28

  Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid lipid walls. The fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.