(2S,3S)-2-(3,5-二甲基苯基)-3-(2-苯基乙基)环戊烷-1-酮 | 824390-77-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 中文名称: (2S,3S)-2-(3,5-二甲基苯基)-3-(2-苯基乙基)环戊烷-1-酮
• 英文名称: 2-(3,5-dimethyl-phenyl)-3-phenethyl-cyclopentanone
• 英文别名: (2S,3S)-2-(3,5-dimethylphenyl)-3-(2-phenylethyl)cyclopentan-1-one
• CAS: 824390-77-4
• 化学式: C₂₁H₂₄O
• 分子量: 292.421
• InChiKey: YKILLDHFANVVKQ-RXVVDRJESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-乙氧基-2-环戊烯酮 在 copper(l) chloride 二苯基硅烷 、 (±)-2,2 '-二(二-对甲苯基膦)-1,1 '-联萘 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 正戊烷 为溶剂， 反应 18.0h， 生成 (2S,3S)-2-(3,5-二甲基苯基)-3-(2-苯基乙基)环戊烷-1-酮
  参考文献：
  名称：

  One-Pot Sequential Cu-Catalyzed Reduction and Pd-Catalyzed Arylation of Silyl Enol Ethers

  摘要：

  {graphic} Enantiomerically enriched beta-substituted diphenylsilyl enol ethers, which can be prepared from Cu-catalyzed asymmetric conjugate reduction, are utilized in the Pd-catalyzed arylation of various aryl bromides. This new method provides a simple route to alpha-arylated cycloalkanones with excellent levels of enantiomeric and diastereomeric purity. The isolation of the intermediate, diphenylsilyl enol ethers is not necessary; the procedure can be carried out in one-pot.

  DOI：

  10.1021/ol048313c

文献信息

• One-Pot Sequential Cu-Catalyzed Reduction and Pd-Catalyzed Arylation of Silyl Enol Ethers
  作者：Junghyun Chae、Jaesook Yun、Stephen L. Buchwald

  DOI：10.1021/ol048313c

  日期：2004.12.1

  graphic} Enantiomerically enriched beta-substituted diphenylsilyl enol ethers, which can be prepared from Cu-catalyzed asymmetric conjugate reduction, are utilized in the Pd-catalyzed arylation of various aryl bromides. This new method provides a simple route to alpha-arylated cycloalkanones with excellent levels of enantiomeric and diastereomeric purity. The isolation of the intermediate, diphenylsilyl enol ethers is not necessary; the procedure can be carried out in one-pot.