(2Z)4,6-二氧代辛-2-烯二酸 | 5698-52-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: (2Z)4,6-二氧代辛-2-烯二酸
• 中文别名: 酪氨酸相关化合物1
• 英文名称: maleylacetoacetic acid
• 英文别名: 4-Maleylacetoacetic acid；(Z)-4,6-dioxooct-2-enedioic acid
• CAS: 5698-52-2
• 化学式: C₈H₈O₆
• 分子量: 200.148
• InChiKey: GACSIVHAIFQKTC-UPHRSURJSA-N

物化性质

• 沸点：
  478.2±40.0 °C(Predicted)
• 密度：
  1.453±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2Z)4,6-二氧代辛-2-烯二酸 在 aqueous acid 作用下， 生成 富马酰乙酰乙酸酯
  参考文献：
  名称：

  KNOX; EDWARDS, Journal of Biological Chemistry, 1955, vol. 216, # 2, p. 489 - 498

  摘要：

  DOI：
• 作为产物：
  描述：

  尿黑酸 在 enzyme-substance from bovine liver 作用下， 生成 (2Z)4,6-二氧代辛-2-烯二酸
  参考文献：
  名称：

  Tokuyama, Journal of Biochemistry, 1959, vol. 46, p. 1453,1454

  摘要：

  DOI：

文献信息

• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Compositions and methods for modeling saccharomyces cerevisiae metabolism
  申请人：The Regents of The University of California

  公开号：EP2463654A1

  公开（公告）日：2012-06-13

  The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive of a S. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention. The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive of a S. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention.

  本发明提供了一种用于确定酿酒葡萄孢菌生理功能的硅胶模型。该模型包括一个将多个酿酒葡萄孢反应物与多个酿酒葡萄孢反应相关联的数据结构、多个酿酒葡萄孢反应的约束集，以及用于确定通过反应的通量分布的指令，该通量分布可预测酿酒葡萄孢的生理功能。本发明的模型可进一步包括一个基因数据库，其中包含表征相关基因的信息。本发明进一步提供了硅胶中酿酒葡萄孢模型的制作方法和使用本发明模型确定酿酒葡萄孢生理功能的方法。本发明提供了一种用于确定酿酒葡萄孢菌生理功能的硅胶模型。该模型包括将多个酿酒葡萄孢反应物与多个酿酒葡萄孢反应相关联的数据结构、多个酿酒葡萄孢反应的约束集，以及用于确定通过反应的通量分布的指令，该通量分布可预测酿酒葡萄孢的生理功能。本发明的模型可进一步包括一个基因数据库，其中包含表征相关基因的信息。本发明进一步提供了制作硅胶葡萄孢菌模型的方法和使用本发明模型确定葡萄孢菌生理功能的方法。
• NEW METHOD OF SYNTHESIS OF CHITOSAN DERIVATIVES AND USES THEREOF
  申请人：Bosti Trading Ltd.

  公开号：EP3865535A1

  公开（公告）日：2021-08-18

  The present invention is directed to a new cross-linked chitosan, preparations, compositions and uses thereof. In particular, the invention relates to nanoparticles and compositions thereof useful as active agents and delivery systems for at least one bioactive agent.

  本发明涉及一种新的交联壳聚糖及其制剂、组合物和用途。特别是，本发明涉及可用作活性剂和至少一种生物活性剂输送系统的纳米颗粒及其组合物。
• Methods of expressing products in mammalian cells
  申请人：Intrexon CEU, INC.

  公开号：US10000770B2

  公开（公告）日：2018-06-19

  The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems.

  本发明涉及新发现的可选择标记系统、用于可选择标记系统的细胞以及使用可选择标记系统的方法。
• Selective hydrogenation method using a nickel-based catalyst produced using an additive comprising a carboxylic acid function
  申请人：IFP Energies nouvelles

  公开号：US10927310B2

  公开（公告）日：2021-02-23

  A process for the selective hydrogenation of polyunsaturated compounds containing at least 2 carbon atoms per molecule, contained in a hydrocarbon feedstock having a final boiling point below or equal to 300° C. in the presence of a catalyst comprising an alumina support and an active phase comprising nickel, said active phase not comprising a metal from Group VIB, said catalyst being prepared by a process comprising at least: i) a step of bringing said support into contact with at least one solution containing at least one nickel precursor; ii) a step of bringing said support into contact with at least one solution containing at least one organic compound comprising at least one carboxylic acid function; iii) a step of drying said impregnated support at a temperature below 250° C.; steps i) and ii) being carried out separately, in any order.

  一种用于选择性氢化烃类原料中所含的每分子至少含 2 个碳原子的多不饱和化合物的工艺，该烃类原料的最终沸点低于或等于 300 摄氏度，催化剂由氧化铝载体和含镍的活性相组成，所述活性相不含 VIB 族金属，所述催化剂的制备工艺至少包括： 1： i) 使所述载体与至少一种含有至少一种镍前体的溶液接触的步骤； ii) 使所述载体与至少一种含有至少一种羧酸功能的有机化合物的溶液接触的步骤； iii) 在低于 250 摄氏度的温度下干燥所述浸渍支撑物； 步骤 i) 和 ii) 可以任意顺序分别进行。