(3,5-二甲氧基苯基)(4-甲氧基苯基)-甲酮 | 94709-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (3,5-二甲氧基苯基)(4-甲氧基苯基)-甲酮
• 英文名称: (3,5-dimethoxyphenyl)(4-methoxyphenyl)methanone
• 英文别名: (3,5-dimethoxyphenyl)-(4-methoxyphenyl)methanone
• CAS: 94709-12-3
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: ZICXUWQPVOZNHU-UHFFFAOYSA-N

物化性质

• 熔点：
  97-98 °C
• 沸点：
  430.2±45.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：30 mg/ml； DMF:PBS (pH 7.2) (1:3)：0.1 mg/ml；二甲基亚砜：20 mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2914509090

反应信息

• 作为反应物：
  描述：

  氰甲基磷酸二乙酯 、 (3,5-二甲氧基苯基)(4-甲氧基苯基)-甲酮 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 正己烷 、 乙酸乙酯 为溶剂， 生成 3-(3,5-Dimethoxy-phenyl)-3-(4-methoxy-phenyl)-acrylonitrile
  参考文献：
  名称：

  Diphenylethylene compounds and uses thereof

  摘要：

  本发明涉及二苯乙烯化合物和包含二苯乙烯化合物的组合物。本发明还涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗各种疾病和紊乱的方法。具体而言，该发明涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗癌症或炎症性紊乱的方法。本发明还涉及包含一种或多种二苯乙烯化合物的制品和工具包。

  公开号：

  US20050107339A1
• 作为产物：
  描述：

  3,5-二甲氧基苯甲酸 在 二硫化碳 、 三氯化铝 、 五氯化磷 作用下， 生成 (3,5-二甲氧基苯基)(4-甲氧基苯基)-甲酮
  参考文献：
  名称：

  Core-level and valence-band characteristics of carbon nitride films with high nitrogen content

  摘要：

  Carbon nitride films with high nitrogen content were prepared by reactive pulsed-laser deposition at nitrogen partial pressures varying from 0.1 to 20.0 Torr. It was found that the nitrogen content in the films first increases with increase of the nitrogen pressure, reaches a maximum of 46 at. % at 5.0 Torr, and then decreases to 37 at. % at 20.0 Torr. The almost pure carbon nitride films were systematically characterized by using X-ray photoelectron spectroscopy (XPS) concerning the core-level and valence-band structures. Some fingerprint information, which shows the role of nitrogen in controlling the electronic structure of carbon nitride films, was found based on the XPS studies. With enhancing the nitrogen incorporation, both the binding energy and the peak intensity of the core-level and the valence-band spectra vary systematically as a function of nitrogen content in the films.

  DOI：

  10.1007/s003390000620

文献信息

• Highly Selective and Divergent Acyl and Aryl Cross-Couplings of Amides via Ir-Catalyzed C–H Borylation/N–C(O) Activation
  作者：Pengcheng Gao、Michal Szostak

  DOI：10.1021/acs.orglett.0c02105

  日期：2020.8.7

  Herein, we demonstrate that amides can be readily coupled with nonactivated arenes via sequential Ir-catalyzed C–H borylation/N–C(O) activation. This methodology provides facile access to biaryl ketones and biaryls by the sterically controlled Ir-catalyzed C–H borylation and divergent acyl and decarbonylative amide N–C(O) and C–C activation. The methodology diverts the traditional acylation and arylation

  在这里，我们证明酰胺可以通过连续的Ir催化的C–H硼酸酯化/ N–C（O）活化而容易地与未活化的芳烃偶联。这种方法可通过空间控制的Ir催化的C–H硼化以及不同的酰基和脱羰基酰胺N–C（O）和C–C活化来轻松获得联芳基酮和联芳基。该方法转移了传统的酰化和芳基化区域选择性，使我们能够直接利用容易获得的芳烃和酰胺来产生有价值的酮和联芳基。
• Palladium nanoparticles supported on a nickel pyrazolate metal organic framework as a catalyst for Suzuki and carbonylative Suzuki couplings
  作者：A. W. Augustyniak、W. Zawartka、J. A. R. Navarro、A. M. Trzeciak

  DOI：10.1039/c6dt02242a

  日期：——

  Methanolic reduction of [PdCl2(CH3CN)2] on a [Ni(2,5-di(1H-pyrazol-4-yl)benzenesulfonate)2] metal organic framework gives rise to Pd2+/Pd0 nanocomposites with Suzuki and carbonylative Suzuki heterogeneous catalytic activities.

  甲醇在[Ni（2,5-二（1 H-吡唑-4-基）苯磺酸盐）2 ]金属有机骨架上还原[PdCl 2（CH 3 CN）2 ]，得到Pd 2+ / Pd 0纳米复合材料具有铃木和羰基化铃木的多相催化活性。
• Structural modification of resveratrol: Sodium resverastatin phosphate
  申请人：Pettit R. George

  公开号：US20050240062A1

  公开（公告）日：2005-10-27

  Described herein are novel compounds having antineoplastic and antimicrobial activity, obtained via structural modifications of resveratrol and combretastatin A-4, methods for synthesis of these compounds, and their use in pharmaceutical composition and for use in the treatment of mammals having cancer. Examples of the novel compounds are: (Z)- and (E)-3,4′,5-trimethioxystilbene (4a, 4b); (Z)- and (E)-3,5-dimethoxy-4′-hydroxystilbene (14c, 14d); (Z)-and (E)-3-hydroxy-4′,5-dimethoxystilbene (14g, 14h);(Z)-and (E)-3,5-dihydroxy-4′-methoxy-stilbene (14k, 14l); sodium resverastatin dibenzyl phosphate ((Z)-3,5-dimethoxy-4-[O-bis(benzyl)phosphoryl]-stilbene) (14m); and sodium resverastatin phosphate (14n).

  本文描述了一些具有抗肿瘤和抗微生物活性的新化合物，这些化合物是通过对白藜芦醇和康布雷他汀A-4进行结构修饰而获得的，还介绍了这些化合物的合成方法以及它们在制药组合物中的使用和用于治疗患有癌症的哺乳动物的用途。新化合物的例子包括：(Z)-和(E)-3,4′,5-三甲氧基亚苄基苯乙烯(4a, 4b)；(Z)-和(E)-3,5-二甲氧基-4′-羟基亚苄基苯乙烯(14c, 14d)；(Z)-和(E)-3-羟基-4′,5-二甲氧基亚苄基苯乙烯(14g, 14h)；(Z)-和(E)-3,5-二羟基-4′-甲氧基-亚苄基苯乙烯(14k, 14l)；白藜芦醇二苄基磷酸钠((Z)-3,5-二甲氧基-4-[O-双苯基磷酸二苄酯基]-亚苄基苯乙烯)(14m)；以及白藜芦醇磷酸钠(14n)。
• POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, AND OPTICAL MATERIAL AND PLASTIC LENS OBTAINED FROM SAME
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3381951A1

  公开（公告）日：2018-10-03

  A polymerizable composition for an optical material of the present invention includes a compound (A) represented by General Formula (1) including two or more allyloxycarbonyl groups; an ultraviolet absorbing agent (B) represented by General Formula (i) ; at least one kind of radical polymerization initiator (C) selected from the group consisting of a peroxyketal-based radical polymerization initiator, a peroxymonocarbonate-based radical polymerization initiator, and a peroxyester-based radical polymerization initiator; at least one kind of dye (D) selected from an anthraquinone-based dye, a perinone-based dye, a monoazo-based dye, a diazo-based dye, and a phthalocyanine-based dye.

  本发明光学材料的可聚合组合物包括通式(1)代表的化合物(A)，其中包括两个或两个以上的烯丙氧羰基；通式(i)代表的紫外线吸收剂(B)；至少一种自由基聚合引发剂 (C)，选自过氧酮基自由基聚合引发剂、过氧一碳酸酯基自由基聚合引发剂和过氧酯基自由基聚合引发剂组成的组； 至少一种染料 (D)，选自蒽醌基染料、过醌基染料、单偶氮基染料、重氮基染料和酞菁基染料。
• POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, MOLDED BODY, OPTICAL MATERIAL, PLASTIC LENS, AND PRODUCTION METHOD FOR PLASTIC LENS
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3722335A1

  公开（公告）日：2020-10-14

  A polymerizable composition for an optical material, comprising: an allyl carbonate compound (A) including two or more allyloxycarbonyl groups at a terminal which is represented by General Formula (1); and a radical polymerization initiator (B), wherein the radical polymerization initiator (B) includes at least one kind of radical polymerization initiator (B1) which is a peroxyester-based radical polymerization initiator in which a radical residual ratio after 5 hours at 50°C is 10% or more and 90% or less, and which has an alkyl group having 5 or more carbon atoms and including a tertiary carbon atom directly connected to an O-O bond, and a radical polymerization initiator (B2) in which a residual radical ratio after 5 hours at 95°C is 10% or more and 90% or less and which is at least one kind selected from the group consisting of a peroxyester-based radical polymerization initiator, a peroxyketal-based radical polymerization initiator, and a peroxymonocarbonate-based radical polymerization initiator.

  一种用于光学材料的可聚合组合物，包括：碳酸烯丙酯化合物（A），其末端含有两个或两个以上的烯丙氧羰基，通式（1）表示该化合物；以及自由基聚合引发剂（B）、 其中自由基聚合引发剂（B）包括 至少一种自由基聚合引发剂 (B1)，它是一种过氧化酯基自由基聚合引发剂，在 50°C 下 5 小时后自由基残留率为 10% 或以上，90% 或以下，它具有一个具有 5 个或更多碳原子的烷基，包括一个直接与 O-O 键连接的叔碳原子，以及 一种自由基聚合引发剂 (B2)，其在 95°C 下 5 小时后的自由基残留率为 10% 或以上，90% 或以下，且至少是一种选自由基聚合引发剂，选自由基聚合引发剂包括：过氧化酯类自由基聚合引发剂、过氧化酮类自由基聚合引发剂和过一碳酸酯类自由基聚合引发剂。