N-(4-methoxyphenyl)-5-nitro-2-[(2E)-2-[(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methylidene]hydrazinyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-methoxyphenyl)-5-nitro-2-[(2E)-2-[(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methylidene]hydrazinyl]benzenesulfonamide
• 化学式: C25H20N6O5S2
• 分子量: 548.6
• InChiKey: VXSVPBOEAKNILB-WGOQTCKBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  180
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] METHODS AND COMPOSITIONS FOR JAMM PROTEASE INHIBITION<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR INHIBITION DE PROTÉASE JAMM
  申请人：CLEAVE BIOSCIENCES INC

  公开号：WO2013123071A1

  公开（公告）日：2013-08-22

  The present invention concerns compounds and corresponding pharmaceutical compositions that display inhibition activity against one or more JAMM proteases. JAMM proteases are involved in the ubiquitin pathway such that inhibition of their enzymatic activity will cause apoptosis. This interdiction provides a method of treatment of neoplastic disease such as but not limited to cancers involving JAMM proteases. The compounds of the invention span a wide range of structures including hydantoins, Schiff bases, hydrazines, hydrazones, carbonyl hydrazones, carbonyl hydrazines, and other complex structural classes.