己烷-1,6-二胺乙酸盐 | 54617-20-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 己烷-1,6-二胺乙酸盐
• 英文名称: hexanediyldiamine; diacetate
• 英文别名: Hexandiyldiamin; Diacetat；hexane-1,6-diamine acetate；acetic acid;hexane-1,6-diamine
• CAS: 54617-20-8
• 化学式: 2C₂H₄O₂*C₆H₁₆N₂
• 分子量: 236.312
• InChiKey: HSKTULZIVGWQHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.56
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,8-二甲氧基-3,4-二氢-1H-2-萘酮 、 己烷-1,6-二胺乙酸盐 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 N,N'-bis(5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthyl)hexamethylenediamine
  参考文献：
  名称：

  Perez; Rosell; Mauleon, Il Farmaco, 1991, vol. 46, # 10, p. 1155 - 1166

  摘要：

  DOI：

文献信息

• [EN] ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] COMPOSÉS SONDES PAR ACTIVITÉ, COMPOSITIONS ET MÉTHODES D'UTILISATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2018119476A1

  公开（公告）日：2018-06-28

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

  提供用于标记半胱氨酸蛋白酶的活性探针化合物。这些化合物通过特定的靶向元素定位到蛋白酶。这些化合物还包括可检测元素，如荧光标记、放射性标记或螯合剂。在某些情况下，这些化合物还包括一种在与蛋白酶反应时释放的熄灭元素。还提供包含这些化合物的组合物和使用这些化合物的方法，例如在动物中标记蛋白酶和在动物中可视化肿瘤。
• ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20160039792A1

  公开（公告）日：2016-02-11

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

  提供用于标记半胱氨酸蛋白酶的活性探针化合物。这些化合物通过特定的靶向元素定向到蛋白酶。这些化合物还包括可检测元素，例如荧光标记、放射性标记或螯合剂。在某些情况下，这些化合物还包括一个在与蛋白酶反应后释放的熄灭元素。还提供了包含这些化合物的组合物和使用这些化合物的方法，例如在动物中标记蛋白酶和可视化动物中的肿瘤。
• Activity-based probe compounds, compositions, and methods of use
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US10100037B2

  公开（公告）日：2018-10-16

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

  提供了用于标记半胱氨酸蛋白酶的基于活性的探针化合物。这些化合物通过特定的靶向元件靶向蛋白酶。化合物还包括可检测元素，如荧光标签、放射性标签或螯合剂。在某些情况下，化合物还包括一种淬灭元素，在与蛋白酶反应时释放出来。此外，还提供了包含这些化合物的组合物和使用这些化合物的方法，例如标记动物体内的蛋白酶和观察动物体内的肿瘤。
• BINDER FOR ABRASIVE ARTICLES, ABRASIVE ARTICLES INCLUDING THE SAME AND METHOD OF MAKING SAME
  申请人：3M Innovative Properties Company

  公开号：EP1425323B1

  公开（公告）日：2012-12-26
• IMAGING AGENTS FOR FUNCTIONAL IMAGING OF LYMPHATIC STRUCTURES
  申请人：Sharma Ruchi

  公开号：US20080056999A1

  公开（公告）日：2008-03-06

  Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid which bind to the receptors. Lymph vascular cell receptor expression may be related to the beginnings of tumor formation. As such, embodiments of the imaging agents may be used to stain lymph structures for detailed imaging of lymph architecture as well as serving as potential markers for tumor angiogenesis, tumor metastases, etc.