(9E,12E,15E)-十八碳-9,12,15-三烯酸钾 | 38660-45-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (9E,12E,15E)-十八碳-9,12,15-三烯酸钾
• 英文名称: α-linolenic acid potassium salt
• 英文别名: potassium α-linolenate；potassium salt of linolenic acid；linolenic acid potassium salt；Potassium (9Z,12Z,15Z)-9,12,15-octadecatrienoate；potassium;(9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• CAS: 38660-45-6
• 化学式: C₁₈H₂₉O₂*K
• 分子量: 316.525
• InChiKey: FKEDIMSDTKPZNV-IFNWOZJISA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.33
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Γ-十八碳三烯酸 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 生成 (9E,12E,15E)-十八碳-9,12,15-三烯酸钾
  参考文献：
  名称：

  Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance

  摘要：

  The role of heart-type fatty acid-binding protein (FABP3) in human physiology as an intracellular carrier of fatty acids (FAs) has been well-documented. In this study, we aimed to develop an analytical method to study real-time interaction kinetics between FABP3 immobilized on the sensor surface and unsaturated C18 FAs using surface plasmon resonance (SPR). To establish the conditions for SPR experiments, we used an FABP3-selective inhibitor 4-(2-(1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl)-phenoxy)-butyric acid. The affinity index thus obtained was comparable to that reported previously, further supporting the usefulness of the SPR-based approach for evaluating interactions between FABPs and hydrophobic ligands. A pseudo-first-order affinity of FABP3 to K+ petroselinate (C18:1 Delta 61 cis), K+ elaidate (C18:1 Delta 9 trans), and K+ oleate (C18:1 Delta 9 cis) was characterized by the dissociation constant (K-d) near micromolar ranges, whereas K+ linoleate (C18:2 Delta 9,12 cis/cis) and K+ alpha-linolenate (C18:3 Delta 9,12,15 cis/cis/cis) showed a higher affinity to FABP3 with K-d around 1 x 10 (6) M. Interactions between FAPB3 and C18 FAs incorporated in large unilamellar vesicles consisting of 1,2-dimyristoyl-sn-glycero-3-phosphocholine and FAs (5:1 molar ratio) were also analysed. Control DMPC liposomes without FA showed only marginal binding to FABP3 immobilized on a sensor chip while liposome-incorporated FA revealed significant responses in sensorgrams, demonstrating that the affinity of FAs to FABP3 could be evaluated by using the liposome-incorporated analytes. Significant affinity to FABP3 was observed for monounsaturated fatty acids (K-d in the range of 1 x 10 (7) M). These experiments demonstrated that highly hydrophobic compounds in a liposome-incorporated form could be subjected to SPR experiments for kinetic analysis. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.02.001

文献信息

• Oxygen-Absorbing Composition And Packaging Material
  申请人：Tsuji Yoshihisa

  公开号：US20080061270A1

  公开（公告）日：2008-03-13

  An oxygen-absorbing composition of the present invention contains a gas-barrier resin as well as a salt of an unsaturated carboxylic acid and an oxygen absorption promoter that are dispersed in the gas-barrier resin A cation that composes the salt of the unsaturated carboxylic acid is a cation of at least one element selected from the group consisting of alkali metals, alkaline earth metals, and aluminum. The oxygen absorption promoter is at least one selected from the group consisting of transition metal salts, radical generators, and photocatalyst particles. The unsaturated carboxylic acid has a molecular weight of 3000 or less.

  本发明的氧气吸收组合物包含一种气体屏障树脂以及分散在气体屏障树脂中的不饱和羧酸盐和氧气吸收促进剂。组成不饱和羧酸盐的阳离子是来自于碱金属、碱土金属和铝等元素组成的至少一种元素的阳离子。氧气吸收促进剂至少包括过渡金属盐、自由基发生剂和光催化剂颗粒中的一种或多种。不饱和羧酸的分子量为3000或更低。
• HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
  申请人：Barton Nelson R.

  公开号：US20110277046A1

  公开（公告）日：2011-11-10

  Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.

  提供了水解酶，包括脂肪酶、饱和酶、棕榈酶和/或硬脂酶，以及编码它们的多核苷酸和制备和使用这些多核苷酸和多肽的方法。进一步提供了多肽，例如酶，具有水解酶活性，例如脂肪酶、饱和酶、棕榈酶和/或硬脂酶，并且提供了制备低饱和或低反式脂肪油的方法，例如低饱和或低反式脂肪动物或植物油，例如大豆油或菜籽油。
• PROCESS FOR PRODUCTION OF LOW SATURATE OILS
  申请人：Dayton Christopher L. G.

  公开号：US20130337515A1

  公开（公告）日：2013-12-19

  Provided here is an enzymatic process for production of low saturate oil, in one embodiment, low palmitic oils from triacylglycerol sources. The enzymes used in the processes herein are saturase enzymes, including palmitase enzymes. The oils produced by the processes herein are used in food products.

  这里提供了一种酶法生产低饱和度油的方法，其中一种实施方式是从三酰甘油来源中生产低棕榈酸油。此处使用的酶是饱和酶，包括棕榈酸酶。由此过程生产的油用于食品产品。
• Detergent-dispersant composition for lubricating or fuel oils
  申请人：KYOWA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0063631A1

  公开（公告）日：1982-11-03

  his invention relates to a detergent-dispersant composition for lubricating or fuel oils, The composition consists essentially of (a) an amount effective as a detergent-dispersant of a hydrotalcite having a specific surface area, determined by the BET method, of up to about 60 m2/g and an average secondary particle size of up to about 5 microns, the hydrotalcite particles being untreated or sulface-treated with an anionic surface-active agent, and the hydrotalcite being represented by the following formula wherein x is a positive number represented by 3

  本发明涉及一种用于润滑油或燃料油的洗涤分散剂组合物，该组合物主要包括(a)一定量的作为洗涤分散剂有效的水滑石，其比表面积用BET法测定可达约60平方米/克，平均二次粒径可达约5微米，水滑石颗粒未经处理或用阴离子表面活性剂进行硫表面处理，水滑石用下式表示 其中 x 是正数，用 3
• Resin, compositions, shaped articles, and methods for manufacture
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0421393A2

  公开（公告）日：1991-04-10

  The resin composition of this invention comprises an isocyanurate ring-containing polyisocyanate such as trimeric hexamethylene-1,6-diisocyanate, an epoxy compound such as bisphenol A epoxy resin, and an aromatic polyamine such as 3,3′-dichloro-4,4′-diaminodi­phenylmethane. This resin composition is particularly suitable for the manufacture of shaped articles to be used in high temperature environments.

  本发明的树脂组合物包括一种含异氰酸酯环的多异氰酸酯（如三聚六亚甲基-1,6-二异氰酸酯）、一种环氧化合物（如双酚 A 环氧树脂）和一种芳香族多胺（如 3,3′-二氯-4,4′-二氨基二苯甲烷）。这种树脂组合物特别适用于制造在高温环境下使用的成型物品。