(Z)-4,6-Dihydro-4-[(3-phenyl-1H-pyrazol-4-yl)methylene]thieno[2,3-b]pyrrol-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (Z)-4,6-Dihydro-4-[(3-phenyl-1H-pyrazol-4-yl)methylene]thieno[2,3-b]pyrrol-5-one
• 英文别名: (4Z)-4-[(5-phenyl-1H-pyrazol-4-yl)methylidene]-6H-thieno[2,3-b]pyrrol-5-one
• 化学式: C₁₆H₁₁N₃OS
• 分子量: 293.349
• InChiKey: HFSWOJWBTQMQBS-JYRVWZFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Thienopyrrolidinones
  申请人：——

  公开号：US20020028841A1

  公开（公告）日：2002-03-07

  The invention is directed to substituted thieno[2,3-b]pyrrolidin-5-ones. The compounds are useful as inhibitors of cellular production of tumor necrosis factor (TNF-&agr;) and as antiproliferative agents. These compounds are useful in the treatment or control of neuro-degenerative diseases, cardiovascular diseases, cancer or inflammatory diseases.

  本发明涉及取代的噻吩并[2,3-b]吡咯烷-5-酮化合物。这些化合物可作为细胞肿瘤坏死因子（TNF-α）生成的抑制剂和抗增殖剂。它们在治疗或控制神经退行性疾病、心血管疾病、癌症或炎症性疾病方面具有应用价值。
• THIENOPYRROLIDINONES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1301517A1

  公开（公告）日：2003-04-16
• US6528653B2
  申请人：——

  公开号：US6528653B2

  公开（公告）日：2003-03-04
• [EN] THIENOPYRROLIDINONES<br/>[FR] THIENOPYRROLIDINONES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002002567A1

  公开（公告）日：2002-01-10

  The present invention provides substituted thieno[2,3-b]pyrrolidin-5-ones of formula (I) wherein R?1, R2, and R3¿ have the values given in the specification. The compounds are useful as inhibitors of cellular production of tumour necrosis factor (TNF-α) and as antiproliferative agents and, therefore, may find use in the treatment of neuro-degenerative diseases, cardiovascular diseases, cancer or inflammatory diseases.