7-(4,5-diphenyl-2-methyl-imidazol-1-yl)-3,5-dihydroxy-heptanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-(4,5-diphenyl-2-methyl-imidazol-1-yl)-3,5-dihydroxy-heptanoic acid
• 英文别名: 3,5-Dihydroxy-7-(2-methyl-4,5-diphenylimidazol-1-yl)heptanoic acid
• 化学式: C₂₃H₂₆N₂O₄
• 分子量: 394.47
• InChiKey: NFYXHCVJSGWHLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  95.6
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Compounds active as inhibitors of the enzyme HMG-CoA reductase and pharmaceutical compositions containing them
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0436851A1

  公开（公告）日：1991-07-17

  Compounds of formula wherein R, R₁, R₂, R₃, R₄ and Z have the meanings reported in the specification, and intermediates for their preparation are described. The compounds of formula I have antiatherosclerotic activity as inhibitors of the enzyme HMG-CoA reductase and they are useful in the pharmaceutical field. Compositions for pharmaceutical use containing a compound of formula I as active ingredient are described too.

  本文描述了公式中R，R₁，R₂，R₃，R₄和Z的含义以及它们的制备中间体。公式I的化合物具有抗动脉粥样硬化活性，作为HMG-CoA还原酶酶的抑制剂在制药领域中有用。本文还描述了含有公式I化合物作为活性成分的制药用组合物。