3-[4-[5-Chloro-2-(4-methylphenyl)pyrazol-3-yl]phenyl]sulfonylpropan-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[4-[5-Chloro-2-(4-methylphenyl)pyrazol-3-yl]phenyl]sulfonylpropan-1-ol
• 化学式: C₁₉H₁₉ClN₂O₃S
• 分子量: 390.9
• InChiKey: ZLYQBUTXPZCYAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  80.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2000018741A2

  公开（公告）日：2000-04-06

  A compound of formula (I), wherein R1 is halo(lower)alkyl, halogen or cyano, R2 is aryl optionally substituted with substituent(s) selected from the group consisting of halogen, lower alkoxy, cyano, nitro, lower alkenyl, amino, acyl and hydroxyimino, R3 is hydrogen, hydroxy, acyloxy, lower alkoxy optionally substituted with lower alkoxy, amino optionally substituted with hydroxy or lower alkyl, lower alkylthio, or lower alkylsulfonyl, R4 is hydrogen or halogen, Q is pyrazolyl, A is lower alkylene optionally substituted with oxo or hydroxy, and n is 0, 1 or 2, provided that when R3 is hydrogen, R2 is aryl substituted with lower alkenyl or A is lower alkylene substituted with oxo, or its salt, processes for their preparation and pharmaceutical compositions.