(9ci)-5-肼基-1H-咪唑-4-羧酸乙酯 | 750524-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: (9ci)-5-肼基-1H-咪唑-4-羧酸乙酯
• 英文名称: ethyl 4-hydrazinyl-1H-imidazole-5-carboxylate
• CAS: 750524-36-8
• 化学式: C₆H₁₀N₄O₂
• mdl: MFCD09959837
• 分子量: 170.17
• InChiKey: LENKOKMNIJOGRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  93
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS<br/>[FR] MÉTHODE DE TRAITEMENT À L'AIDE DE MODULATEURS DE L'ACIDE AMINOLÉVULINIQUE SYNTHASE 2 (ALAS2)
  申请人：AGIOS PHARMACEUTICALS INC

  公开号：WO2020247819A2

  公开（公告）日：2020-12-10

  Described herein is a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein Ring A R1, R2, a, b, and n are as defined herein. Also described is a method of treating a subject having a disorder in need of treatment, comprising inhibiting aminolevulinic acid synthase 2 (ALAS2) in the subject by administering a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Disorders that are of particular interest are blood disorders, such as porphyria and anemia.