(3Z)-3-[(3-chloropyridin-4-yl)methylidene]-6-methoxy-2-benzofuran-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: (3Z)-3-[(3-chloropyridin-4-yl)methylidene]-6-methoxy-2-benzofuran-1-one
• 化学式: C₁₅H₁₀ClNO₃
• 分子量: 287.7
• InChiKey: FCIFQZUFKQCYDZ-NSIKDUERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Process for the preparation of (pyridinylidene)-phthalides
  申请人：——

  公开号：US20030023094A1

  公开（公告）日：2003-01-30

  A process for the preparation of (pyridinylidene)-phthalides starting from 3-oxo-1,3-dihydro-isobenzofuran-1-carboxylic acids and pyridinecarbaldehydes, is described.

  本发明描述了一种从3-氧代-1,3-二氢异苯并呋喃-1-羧酸和吡啶醛开始制备（吡啶基亚甲基）邻苯二酸酐的方法。
• Phthalazine derivatives phosphodiesterase 4 inhibitors
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP1371648A1

  公开（公告）日：2003-12-17

  Compounds of formula wherein ----- is a single or double bond; Z is NH, methylene, a (C2-C6)alkylene chain optionally branched and/or unsaturated and/or interrupted by a (C5-C7)cycloalkyl residue; A is phenyl or heterocycle optionally substituted by one or more substituent(s) selected among oxo, nitro, carboxy groups and halogen atoms, or a COR4 group wherein R4 is hydroxy, (C1-C6)-alkoxy, amino optionally substituted by one or two (C1-C6)alkyl group(s) or by hydroxy; R is a (C1-C6)alkyl or polyfluoro(C1-C6)alkyl group; R1 is absent when ----- is a double bond or, when ----- is a single bond, is (a) hydrogen; (b) (C1-C6)alkyl optionally substituted by aryl, by heterocycle or by a COR5 group wherein R5 is hydroxy, (C1-C4)alkoxy or hydroxamino; (c)-COR6 wherein R6 is hydrogen, aryl, aryl-(C1-C6)alkyl, amino optionally alkylated or monohydroxylated, hydroxy, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, or (C1-C4)alkyl optionally substituted by heterocycle; (d) (C1-C4)-alkylsulfonyl; R2 represents two hydrogen atoms or a group =O when ----- is a single bond, or, when ----- is a double bond, R2 is hydrogen, cyano, (C1-C4)alkoxycarbonyl, amido, optionally substituted aryl or heterocycle, (C1-C8)alkyl, (C2-C8)alkenyl or (C2-C8)alkynyl optionally branched and/or substituted by aryl or heterocycle; aryloxy, heterocyclyloxy, aryl-(C1-C4)alkoxy, heterocyclyl-(C1-C4)alkoxy, amino substituted by one or two (C1-C4)-alkyl group(s), arylamino, heterocyclylamino, aryl-(C1-C4)alkylamino, heterocyclyl-(C1-C4)-alkylamino; R3 is hydrogen, or a (C1-C8)alkyl, (C2-C8)alkenyl or (C2-C8)alkynyl group optionally substituted by hydroxy, oxo, aryl or heterocycle, and optionally interrupted by one or more heteroatom(s) or heterogroup(s); the N→O derivatives of the compounds of formula I and the pharmaceutically acceptable salts thereof are PDE 4 inhibitors.

  式中的化合物 其中 ----- 是单键或双键；Z 是 NH、亚甲基、任选支化和/或不饱和和/或被(C5-C7)环烷基残基打断的(C2-C6)亚烷基链；A 是苯基或杂环，任选被选自氧代、硝基、羧基和卤素原子中的一个或多个取代基或 COR4 基团取代，其中 R4 是羟基、(C1-C6)-烷氧基、任选被一个或两个(C1-C6)烷基取代的氨基或羟基；R 是(C1-C6)烷基或多氟(C1-C6)烷基；当 ----- 为双键时，R1 不存在，或当 ----- 为单键时，R1 是 (a) 氢；(b) 可选择被芳基、杂环或 COR5 基团取代的(C1-C6)烷基，其中 R5 是羟基、(C1-C4)烷氧基或羟基氨基；(c)-COR6 其中 R6 是氢、芳基、芳基-(C1-C6)烷基、任选被烷基化或单羟基 化的氨基、羟基、(C1-C4)烷氧基、羧基、(C1-C4)烷氧羰基、 (d) (C1-C4)-烷基磺酰基；当 ----- 为单键时，R2 代表两个氢原子或一个基团 =O；当 ----- 为双键时，R2 代表氢、氰基、(C1-C4)烷氧基羰基、氨基、任选取代的芳基或杂环、任选支化和/或被芳基或杂环取代的 (C1-C8)烷基、(C2-C8)烯基或(C2-C8)炔基；芳氧基、杂环氧基、芳基-(C1-C4)烷氧基、杂环-(C1-C4)烷氧基、被一个或两个 (C1-C4)- 烷基取代的氨基、芳基氨基、杂环氨基、芳基-(C1-C4)烷基氨基、杂环-(C1-C4)-烷基氨基；式 I 化合物的 N→O 衍生物及其药学上可接受的盐类是 PDE 4 抑制剂。
• US6706882B2
  申请人：——

  公开号：US6706882B2

  公开（公告）日：2004-03-16
• US6894164B2
  申请人：——

  公开号：US6894164B2

  公开（公告）日：2005-05-17