(2S,4S)-2-(4-hydroxyphenyl)-4-methyl-3,4-dihydro-2H-chromen-6-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2S,4S)-2-(4-hydroxyphenyl)-4-methyl-3,4-dihydro-2H-chromen-6-ol
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.3
• InChiKey: SZQZCUFSICWVPL-QFYYESIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] ESTROGEN RECEPTOR BETA (ERβ) AGONISTS FOR THE TREATMENT OF FIBROTIC CONDITIONS<br/>[FR] AGONISTES DU RÉCEPTEUR BÊTA DES OESTROGÈNES (ERβ) POUR LE TRAITEMENT D'ÉTATS FIBROTIQUES
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2020160225A1

  公开（公告）日：2020-08-06

  Disclosed are method of treating fibrotic conditions using estrogen receptor β (ERβ) agonists.
• [EN] METHODS OF MODULATING T-CELL ACTIVATION USING ESTROGEN RECEPTOR BETA (ERΒ) AGONISTS<br/>[FR] MÉTHODES DE MODULATION DE L'ACTIVATION DES LYMPHOCYTES T À L'AIDE D'AGONISTES DU RÉCEPTEUR BÊTA DES ŒSTROGÈNES (ERΒ)
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2021183760A1

  公开（公告）日：2021-09-16

  Disclosed are method of modulating immune response in a subject using ERβ agonists. The ERβ agonists can selectively inhibit the activation and/or proliferation of T-cells, reducing circulating T-cell levels in a subject without significantly affecting circulating levels of neutrophils, monocytes, or B-cells. As a result, the ERβ agonists can be used in therapeutic and/or prophylactic applications, including to treat or prevent chronic heart failure (CHF) in a subject post-myocardial infarction (MI) and to treat or prevent graft-versus-host disease (GVHD), multiple sclerosis (MS), and/or experimental autoimmune encephalomyelitis (EAE) in a subject.