(E)-3-羟基辛-6-烯酸 | 128940-64-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: (E)-3-羟基辛-6-烯酸
• 英文名称: 3-Hydroxy-6-octenoic acid
• 英文别名: (E)-3-hydroxyoct-6-enoic acid
• CAS: 128940-64-7
• 化学式: C₈H₁₄O₃
• 分子量: 158.19
• InChiKey: UYHGBTRCKCDOGE-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Method for producing microbial polyester
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1113076A2

  公开（公告）日：2001-07-04

  A method for producing a microbial polyester by culturing a microorganism being capable of producing a poly hydroxyalkanoate polyester in a culture medium containing 1-hexene as a sole carbon source.

  一种生产微生物聚酯的方法，在含有 1-己烯作为唯一碳源的培养基中培养能够生产聚羟基烷酸酯聚酯的微生物。
• METHOD FOR PREPARING POLYLACTATE AND COPOLYMER THEREOF USING A MUTANT MICROORGANISM WITH ENHANCED POLYLACTATE, AND THE COPOLYMER PRODUCING CAPABILITY THEREOF
  申请人：LG Chem, Ltd.

  公开号：EP2314638A2

  公开（公告）日：2011-04-27

  Provided is a method of preparing polylactate (PLA) or a copolymer thereof using a mutant microorganism in which a gene participating in a coenzyme A (CoA) donor- and lactate-producing pathway is genetically manipulated to increase the productivity of a CoA donor and lactate. Amounts of the CoA donor and the lactate are simultaneously increased in a microbial metabolic pathway to enable effective biosynthesis of PLA and a hydroxyalkanoate-lactate copolymer having a high content of lactate, which is industrially useful.

  本发明提供了一种利用突变微生物制备聚乳酸（PLA）或其共聚物的方法，在这种突变微生物中，参与辅酶A（CoA）供体和乳酸盐产生途径的基因受到遗传操作，以提高CoA供体和乳酸盐的产量。在微生物代谢途径中，CoA 供体和乳酸盐的数量同时增加，从而能够有效地生物合成聚乳酸和具有高乳酸盐含量的羟基烷酸-乳酸盐共聚物，这在工业上是有用的。
• PREPARATION METHOD OF LACTATE POLYMERS AND LACTATE COPOLYMERS USING POLYHYDROXYALKANOATE SYNTHASE MUTANTS
  申请人：LG Chem, Ltd.

  公开号：EP2471910A2

  公开（公告）日：2012-07-04

  Mutants of various polyhydroxyalkanoate (PHA) synthases capable of synthesizing a lactate polymer (PLA) and a lactate copolymer (PLA copolymer), and a method of preparing a lactate polymer and a lactate copolymer using the same are provided. More specifically, a mutant of polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8, and a method of preparing lactate polymer and lactate copolymer using the mutant of synthase are provided. The polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8 can have an activity of synthesizing a lactate polymer and a lactate copolymer by an amino acid sequence mutation affecting an activity of synthesizing a lactate polymer, and can produce a lactate polymer and a copolymer that have different features, respectively, by using the mutants of the synthase.

  本发明提供了能够合成乳酸聚合物（聚乳酸）和乳酸共聚物（聚乳酸共聚物）的各种聚羟基烷酸（PHA）合酶的突变体，以及使用这些突变体制备乳酸聚合物和乳酸共聚物的方法。更具体地说，提供了 SEQ ID NO:2、4、6 或 8 所述的聚羟基烷酸合酶突变体，以及使用该合酶突变体制备乳酸聚合物和乳酸共聚物的方法。SEQ ID NO:2、4、6 或 8 所述的聚羟基烷酸合酶可通过影响合成乳酸聚合物活性的氨基酸序列突变而具有合成乳酸聚合物和乳酸共聚物的活性，并可通过使用该合酶的突变体生产分别具有不同特征的乳酸聚合物和共聚物。
• Mutant of propionyl-CoA transferase from Clostridium propionicum and preparing method for PLA or PLA copolymer using the same
  申请人：LG Chem, Ltd.

  公开号：EP2636744A1

  公开（公告）日：2013-09-11

  Provided is a mutant of propionyl-CoA transferase from Clostridium propionicum that can convert lactate into lactyl-CoA with high efficiency in a method of preparing a polylactate (PLA) or PLA copolymer using microorganisms. Unlike conventional propionyl-CoA transferase which is weakly expressed in E.coli, when a mutant of propiony-CoA transferase from Clostridium propionicum is introduced into recombinant E.coli, lactyl-CoA can be supplied very smoothly, thereby enabling highly efficient preparation of polylactate (PLA) and PLA copolymer.

  本文提供了一种来自丙酸梭菌的丙酰-CoA 转移酶突变体，在利用微生物制备聚乳酸（PLA）或聚乳酸共聚物的方法中，该突变体可高效地将乳酸转化为乳酰-CoA。与传统的丙酰基-CoA 转移酶在大肠杆菌中弱表达不同，当将丙酸梭状芽孢杆菌的丙酰基-CoA 转移酶突变体引入重组大肠杆菌时，乳酰-CoA 的供应非常顺畅，从而能够高效制备聚乳酸（PLA）和聚乳酸共聚物。
• Preparation method of lactate polymers and lactate copolymers using polyhydroxyalkanoate synthase mutants
  申请人：LG Chem, Ltd.

  公开号：EP2650372A2

  公开（公告）日：2013-10-16

  Mutants of various polyhydroxyalkanoate (PHA) synthases capable of synthesizing a lactate polymer (PLA) and a lactate copolymer (PLA copolymer), and a method of preparing a lactate polymer and a lactate copolymer using the same are provided. More specifically, a mutant of polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8, and a method of preparing lactate polymer and lactate copolymer using the mutant of synthase are provided. The polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8 can have an activity of synthesizing a lactate polymer and a lactate copolymer by an amino acid sequence mutation affecting an activity of synthesizing a lactate polymer, and can produce a lactate polymer and a copolymer that have different features, respectively, by using the mutants of the synthase.

  本发明提供了能够合成乳酸聚合物（聚乳酸）和乳酸共聚物（聚乳酸共聚物）的各种聚羟基烷酸（PHA）合酶的突变体，以及使用这些突变体制备乳酸聚合物和乳酸共聚物的方法。更具体地说，提供了 SEQ ID NO:2、4、6 或 8 所述的聚羟基烷酸合酶突变体，以及使用该合酶突变体制备乳酸聚合物和乳酸共聚物的方法。SEQ ID NO:2、4、6 或 8 所述的聚羟基烷酸合酶可通过影响合成乳酸聚合物活性的氨基酸序列突变而具有合成乳酸聚合物和乳酸共聚物的活性，并可通过使用该合酶的突变体生产分别具有不同特征的乳酸聚合物和共聚物。