异丙基甘氨酸叔丁酯 | 127983-07-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 异丙基甘氨酸叔丁酯
• 英文名称: isopropylamino-acetic acid tert-butyl ester
• 英文别名: tert-butyl isopropylglycinate；tert-butyl N-isopropylglycinate；Tert-butyl 2-[(propan-2-yl)amino]acetate；tert-butyl 2-(propan-2-ylamino)acetate
• CAS: 127983-07-7
• 化学式: C₉H₁₉NO₂
• mdl: MFCD12148600
• 分子量: 173.255
• InChiKey: NGSAOBOSMSHVEN-UHFFFAOYSA-N

物化性质

• 沸点：
  206.4±23.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  异丙基甘氨酸叔丁酯 在 sodium methylate 、 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 7.16h， 生成
  参考文献：
  名称：

  New prototypical O-linked-glycopeptidomimetics corresponding to the linkage region of proteoglycans

  摘要：

  A new class of glycopeptidomimetic composed of N-substituted oligoglycine (peptoid) mimicking the beta-D-Xyl-(1 --> 3)-O-L-Ser linkage region of proteoglycans was synthesized using a convergent approach. Reiterative N-alkylation-N-bromoacetylation reactions were used starting from tert-butyl bromoacetate (1) and isopropylamine. Perbenzoylated 2-aminoethyl beta-D-xylopyranoside 10 constituted the key glycan L-Ser mimic. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(96)00301-1
• 作为产物：
  描述：

  溴乙酸叔丁酯 、 异丙胺 在 吡啶 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以75%的产率得到异丙基甘氨酸叔丁酯
  参考文献：
  名称：

  Synthesis of new glycopeptidomimetics based on N-substituted oligoglycine bearing an N-linked lactoside side-chain

  摘要：

  一种新的模型N-取代寡甘氨酸（肽类物质）家族被合成，该结构包含一个N-连接的乳糖侧链，合成采用了收敛和重复的方法，使用了叔丁基溴乙酸酯和初级胺作为构建模块。

  DOI：

  10.1039/c39950002571

文献信息

• [EN] SUBSTITUTED SULFONAMIDE COMPOUNDS<br/>[FR] COMPOSÉS DE SULFONAMIDE SUBSTITUÉS
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014049047A1

  公开（公告）日：2014-04-03

  The invention is concerned with the compounds of formula (I), and salts thereof, wherein X, Y, Z, R1, R2, R3, R3, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

  本发明涉及公式(I)的化合物及其盐，其中X、Y、Z、R1、R2、R3、R3、R4、R5和R6在详细描述和权利要求中定义。此外，本发明还涉及制造和使用公式(I)化合物的方法，以及含有此类化合物的药物组合物。这些化合物可能对治疗由TRPA1介导的疾病和状况，如疼痛，有益。
• [EN] BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF<br/>[FR] COMPOSÉS BENZOPYRAZOLE ET ANALOGUES DE CEUX-CI
  申请人：BIOCRYST PHARM INC

  公开号：WO2017136395A1

  公开（公告）日：2017-08-10

  Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof. The compounds are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising a compound of formula (I), and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by aberrant complement system activity.

  揭示了式（I）的化合物及其药学上可接受的盐。这些化合物是裂解系统的抑制剂。还提供了包含式（I）化合物的药物组合物，以及涉及使用这些化合物和组合物在治疗和预防由异常裂解系统活性特征的疾病和状况中的方法。
• [EN] N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES<br/>[FR] DÉRIVÉS DE N-(3-(2-(4-CHLOROPHÉNOXY)ACÉTAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE ET COMPOSÉS APPARENTÉS EN TANT QU'INHIBITEURS ATF4 POUR LE TRAITEMENT DU CANCER ET D'AUTRES MALADIES
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2019008506A1

  公开（公告）日：2019-01-10

  The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein X, a, b, C, D, L2, L3, Y1, Y2, R2, R4, R5, R6, z2, z4, z5, and z6 are as defined herein, and salts thereof. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to compounds for use in methods of inhibiting the ATF4 (activating transcription factor 4) pathway and treatment of disorders associated therewith, such as e.g. cancer, neurodegenerative diseases and many other diseases, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. Preferred compounds of the invention are N-(3-(2-(4-chlorophenoxy) acetamido)bicyclo[1.1.1]pentan-l-yl)-2-cyclobutane-l-carboxamide derivatives and related compounds.

  该发明涉及替代的桥接环戊烷衍生物。具体而言，该发明涉及根据式（I）的化合物，其中X、a、b、C、D、L2、L3、Y1、Y2、R2、R4、R5、R6、z2、z4、z5和z6如本文所定义，并其盐。该发明还涉及包含该发明化合物的药物组合物。该发明还涉及用于抑制ATF4（激活转录因子4）途径和治疗相关疾病的方法的化合物，例如癌症、神经退行性疾病和许多其他疾病，使用该发明化合物或包含该发明化合物的药物组合物。该发明的优选化合物是N-(3-(2-(4-氯苯氧基)乙酰氨基)双环[1.1.1]戊烷-1-基)-2-环丁烷-1-羧酰胺衍生物及相关化合物。
• Imidazothiazole derivatives
  申请人：Kawato Haruko

  公开号：US20090312310A1

  公开（公告）日：2009-12-17

  There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R 1 , R 2 , R 3 , R 4 , and R 5 in the formula (1) each has the same meaning as defined in the specification.

  提供了一种新的化合物，它抑制小鼠双分子分钟2（Mdm2）蛋白与p53蛋白之间的相互作用，并展现出抗肿瘤活性。本发明提供了一种咪唑噻唑衍生物，其表示为以下公式（1），具有各种取代基，可抑制Mdm2蛋白与p53蛋白之间的相互作用并展现出抗肿瘤活性：其中，公式（1）中的R1、R2、R3、R4和R5每个都具有规范中定义的相同含义。
• SUBSTITUTED SULFONAMIDE SOLUTIONS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150197509A1

  公开（公告）日：2015-07-16

  The invention is concerned with the compounds of formula (I): and salts thereof, wherein X, Y, Z, R 1 , R 2 , R 3 , R 3′ , R 4 , R 5 and R 6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

  本发明涉及公式（I）的化合物及其盐，其中X、Y、Z、R1、R2、R3、R3'、R4、R5和R6在详细说明和权利要求中有定义。此外，本发明还涉及制备和使用公式（I）化合物的方法，以及包含这些化合物的制药组合物。这些化合物可能对治疗由TRPA1介导的疾病和病症，如疼痛，有用。