(E)-5-(2-(7-azabicyclo[2.2.1]hept-2-yl)ethenyl)isoxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (E)-5-(2-(7-azabicyclo[2.2.1]hept-2-yl)ethenyl)isoxazole
• 英文别名: (E)-5-(2-(7-azabicyclo[2.2.1]hept-2-yl)vinyl)isoxazole；5-[(E)-2-(7-azabicyclo[2.2.1]heptan-2-yl)ethenyl]-1,2-oxazole
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: OGGMLAWMMPHDST-HNQUOIGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  38.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pharmaceutical compositions and methods for use
  申请人：——

  公开号：US20020160998A1

  公开（公告）日：2002-10-31

  The present invention relates to aryl olefinic azacyclic compounds and aryl acetylenic azacylic compounds. The present invention relates in particular to five-membered heteroaromatic olefinic azacyclic compounds and five-membered heteroaromatic acetylenic azacylic compounds, including isoxazolyl olefinic cycloalkylamines and isoxazolyl acetylenic cycloalkylamines.

  本发明涉及芳基烯烃氮杂环化合物和芳基乙炔基氮杂环化合物。本发明特别涉及五元杂环芳基烯烃氮杂环化合物和五元杂环芳基乙炔基氮杂环化合物，包括异噁唑烯烃环烷胺和异噁唑基乙炔基环烷胺。
• AZABICYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE
  申请人：Targacept, Inc.

  公开号：EP1305316A2

  公开（公告）日：2003-05-02
• US6624167B1
  申请人：——

  公开号：US6624167B1

  公开（公告）日：2003-09-23
• US7022706B2
  申请人：——

  公开号：US7022706B2

  公开（公告）日：2006-04-04
• [EN] PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE<br/>[FR] COMPOSITIONS PHARMACEUTIQUES ET PROCEDES D'UTILISATION
  申请人：TARGACEPT INC

  公开号：WO2002012245A2

  公开（公告）日：2002-02-14

  Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and disorders associated with dysfunction of the central and autonomic nervous systems can be treated using pharmaceutical compositions incorporating compounds in which an aromatic ring is bridged with an ethylenic or acetylenic unit to an azabicyclic moiety.