N-(3-bromophenyl)-4-[4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(3-bromophenyl)-4-[4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine
• 化学式: C₁₉H₁₃BrFN₅
• 分子量: 410.2
• InChiKey: AWIVQFPJACMEKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ANTI-INFLAMMATORY 4-PHENYL-5-PYRIMIDINYL-IMIDAZOLES<br/>[FR] 4-PHENYL-5-PYRIMIDINYL-IMIDAZOLES ANTI-INFLAMMATOIRES
  申请人：NOVARTIS AG

  公开号：WO2000026209A1

  公开（公告）日：2000-05-11

  Novel 4- phenyl- 5-(2- aryl-X)- 4-pyrimidinyl-, 4- phenyl-5- (2-cycloalkyl- X)-4-pyrimidinyl-, 4- phenyl-5- (-aralkyl-X)-4- pyrimidinyl- or 4-phenyl- 5-(2-cycloalkylalkyl- X)-4-pyrimidinyl- imidazoles, in which the 5- pyrimidinyl substituent is aryl, cycloalkyl, aralkyl or cycloalkylalkyl substituted directly via a heteroatom X selected from N, O or S, and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof are provided, in particular compounds of formula (I), wherein the symbols are as defined, which are MAP kinase inhibitors, useful pharmaceutically for treating TNFα and IL-1 mediated diseases such as rheumatoid arthritis and diseases of bone metabolism, e.g. osteoporosis.