N-[(4-methylphenoxy)carbonyl]-N-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}glycine | 331741-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[(4-methylphenoxy)carbonyl]-N-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}glycine
• 英文别名: 2-[(4-Methylphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid
• CAS: 331741-93-6
• 化学式: C₂₉H₂₈N₂O₆
• 分子量: 500.551
• InChiKey: DBGYNSCUCADJHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
  申请人：Cheng T. Peter

  公开号：US20070015797A1

  公开（公告）日：2007-01-18

  Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

  提供了一些化合物，它们的结构如下：其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R1、R2、R2a、R2b、R2c、R3、Y、x、m和n如此定义，这些化合物可用作抗糖尿病、降脂和抗肥胖药物。
• ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA
  申请人：Sakuma Shogo

  公开号：US20090298896A1

  公开（公告）日：2009-12-03

  A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein G a is O, CH 2 or the like; A a is thiazole, oxazole, or thiophene, which can have a substituent such as C 1-8 alkyl, C 1-8 alkoxy, halogen, C 1-8 alkyl substituted with halogen or the like; B a is a C 1-8 alkylene or C 2-8 alkenylene chain; and each of R 1a and R 2a independently is hydrogen, C 1-8 alkyl, C 1-8 alkoxy, halogen, C 1-8 alkyl substituted with halogen or the like.

  以下通式（II）所代表的化合物或其盐被用作PPARδ的激活剂。其中G是O，CH2或类似物；A是噻唑、噁唑或噻吩，可以具有C1-8烷基、C1-8烷氧基、卤素、C1-8卤代烷基或类似物的取代基；B是C1-8烷基或C2-8烯基烷链；R1a和R2a各自独立地是氢、C1-8烷基、C1-8烷氧基、卤素、C1-8卤代烷基或类似物。
• Activator for Peroxisome Proliferator-Activated Receptor
  申请人：Sakuma Shogo

  公开号：US20090203908A1

  公开（公告）日：2009-08-13

  A compound having the following formula or its salt is used as an activator for PPAR: in which W 2 represents a bond, C(═O) or CH 2 ; Z 2 represents an oxygen or sulfur atom; R 21 , R 22 and R 23 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom or the like; and R 24 and R 25 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom.

  以下化合物或其盐被用作PPAR的激活剂：其中W2代表一个化学键，C（═O）或CH2; Z2代表一个氧原子或硫原子; R21、R22和R23独立地代表氢原子、具有1至8个碳原子的烷基、具有1至8个碳原子的烷氧基、卤素原子、具有1至8个碳原子的烷基，该烷基被卤素原子或类似物取代; R24和R25独立地代表氢原子、具有1至8个碳原子的烷基或具有1至8个碳原子的烷基，该烷基被卤素原子取代。
• Oxa-and thiazole derivatives useful as antidiabetic and antiobesity agents
  申请人：Bristol-Myers Squibb Company

  公开号：EP1939188A1

  公开（公告）日：2008-07-02

  Compounds are provided which have structure (I), wherein Q is C or N; A is O or S; Z is O or a bond; X is CH or N and R1, R2, R2a, R2b, R2c, R3 Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

  提供了具有结构（I）的化合物，其中 Q 是 C 或 N；A 是 O 或 S；Z 是 O 或键；X 是 CH 或 N，R1、R2、R2a、R2b、R2c、R3 Y、x、m 和 n 如本文所定义，这些化合物可用作抗糖尿病、降血脂和抗肥胖药物。
• ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：EP2014652B1

  公开（公告）日：2014-08-06