3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-5-(hexyl-methylamino)-4-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-5-(hexyl-methylamino)-4-oxopentanoic acid
• 英文别名: 3-[2-[5-tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-5-[hexyl(methyl)amino]-4-oxopentanoic acid
• 化学式: C₂₈H₄₅N₇O₆
• 分子量: 575.7
• InChiKey: XIMITGPWYYFUQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  41
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  170
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Agents for use in the treatment of glioma
  申请人：DC EUROPA LIMITED

  公开号：US11246927B2

  公开（公告）日：2022-02-15

  The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO IΓ and 111°, as well as IV0 (glioblastoma), in a subject.

  本发明涉及用于治疗胶质瘤的药物，特别是用于治疗WHO IΓ和111°以及IV0（胶质母细胞瘤）的星形细胞瘤。
• AGENTS FOR USE IN THE TREATMENT OF GLIOMA
  申请人：RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG

  公开号：US20180221479A1

  公开（公告）日：2018-08-09

  The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO IF and 111°, as well as IV0 (glioblastoma), in a subject.
• AGENT FOR USE IN THE TREATMENT OF GLIOMA
  申请人：DC EUROPA LIMITED

  公开号：US20220202936A1

  公开（公告）日：2022-06-30

  The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO II° and III°, as well as IV° (glioblastoma), in a subject.