4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide;2-[4-(2-methylpropyl)phenyl]propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide;2-[4-(2-methylpropyl)phenyl]propanoic acid
• 化学式: C30H32F3N3O4S
• 分子量: 587.7
• InChiKey: GZBWQNWKJLJQJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.59
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• METHODS AND COMPOSITIONS FOR TREATMENT OF MITOCHONDRIAL TOXICITY
  申请人：CARDERO THERAPEUTICS, INC.

  公开号：US20190046517A1

  公开（公告）日：2019-02-14

  The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to ameliorate mitochondrial toxicity caused by administration of a chemical, food, or drug.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING OVULATION<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE L'OVULATION
  申请人：HOURVITZ ARIEL

  公开号：WO2020141509A1

  公开（公告）日：2020-07-09

  Compositions, methods and kits for inhibiting ovulation in a female subject are provided, which utilize inhibitors of the prostaglandin E2 transporter ABCC4, alone or in combination with inhibitors of prostaglandin synthesis.