3-[3-(7-Methylimidazo[1,2-a]pyridin-3-yl)phenyl]thiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[3-(7-Methylimidazo[1,2-a]pyridin-3-yl)phenyl]thiophene-2-carboxamide
• 化学式: C₁₉H₁₅N₃OS
• 分子量: 333.4
• InChiKey: RFTAMXNGHRQDQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  88.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1235827A2

  公开（公告）日：2002-09-04
• [EN] IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES D'IMIDAZO-PYRIDINE UTILISES COMME LIGANDS POUR RECEPTEURS DE GABA
  申请人：MERCK SHARP & DOHME

  公开号：WO2001038326A2

  公开（公告）日：2001-05-31

  A class of 3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, are selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.