3-(2,4-diphenylimidazol-1-yl)-N-methylpropanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2,4-diphenylimidazol-1-yl)-N-methylpropanamide
• 化学式: C₁₉H₁₉N₃O
• 分子量: 305.4
• InChiKey: QNYWCNPETZFQAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• AMINO-KETONE SOLID SUPPORT TEMPLATES
  申请人：Advanced syntech, LLC

  公开号：EP1153050A1

  公开（公告）日：2001-11-14
• EP1153050A4
  申请人：——

  公开号：EP1153050A4

  公开（公告）日：2002-11-27
• US6117940A
  申请人：——

  公开号：US6117940A

  公开（公告）日：2000-09-12
• [EN] AMINO-KETONE SOLID SUPPORT TEMPLATES<br/>[FR] MATRICES A L'AMINO-CETONE POUR SUPPORTS SOLIDES
  申请人：ADVANCED SYNTECH LLC

  公开号：WO2000023487A1

  公开（公告）日：2000-04-27

  A solid support template for solid phase synthesis of amino group containing compounds is provided that comprises amino-ketone core compounds of the general formula: A-L-NH(CR1R2)nCOR3 linked to appropriate insoluble substrates to create solid support templates having the general formula: Polymer-X-L-NH(CR1R2)nCOR3 where L is a multifunctional monomer carrying a first functional group that forms a covalent bond with X and a second functional group comprising an amine and L, R1, R2 and R3 are selected from the group consisting of alkyl, alkyl-aryl, alkenyl, alkenyl-aryl groups having up to 6 carbon atoms and substituted forms thereof. The amino-ketones templates are useful for the solid phase synthesis of compounds such as the imidazoles, benzodiazepines, pyrazines, and steroid mimics.