N,N-dimethyl-4-(1-methyl-4-(3,4,5-trimethoxyphenyl)-1H-imidazol-5-yl)aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N,N-dimethyl-4-(1-methyl-4-(3,4,5-trimethoxyphenyl)-1H-imidazol-5-yl)aniline
• 英文别名: N,N-dimethyl-4-[3-methyl-5-(3,4,5-trimethoxyphenyl)imidazol-4-yl]aniline
• 化学式: C₂₁H₂₅N₃O₃
• 分子量: 367.448
• InChiKey: OULLSLFNUYNIOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• IMIDAZOLE ANTIPROLIFERATIVE AGENTS
  申请人：Abbott Laboratories

  公开号：EP1200412A2

  公开（公告）日：2002-05-02
• US6201001B1
  申请人：——

  公开号：US6201001B1

  公开（公告）日：2001-03-13
• [EN] IMIDAZOLE ANTIPROLIFERATIVE AGENTS<br/>[FR] AGENTS ANTIPROLIFERATIFS IMIDAZOLE
  申请人：ABBOTT LAB

  公开号：WO2001009103A2

  公开（公告）日：2001-02-08

  Compounds of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, and isolpropyl; and one of R2 or R3 is 3,4,5-trimethoyxphenyl, and the other is phenyl substituted with one, two, or three substitutents independently selected from the group consisting of alkoxy, halo, and -NR4R5, wherein R?4 and R5¿ are independently selected from the group consisting of hydrogen and alkyl, inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.