6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-phthalan-5-yl)-4-methyl-hex-4t-ensaeure-amid, Mycophenolsaeureamid | 31858-64-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-phthalan-5-yl)-4-methyl-hex-4t-ensaeure-amid, Mycophenolsaeureamid
• 英文别名: mycophenolic acid amide；(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enamide
• CAS: 31858-64-7
• 化学式: C₁₇H₂₁NO₅
• 分子量: 319.357
• InChiKey: WWOOEYCTHQFRGE-RUDMXATFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  98.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PROCESS FOR THE PREPARATION OF MYCOPHENOLIC ACID AND DERIVATIVES THEREOF
  申请人：Gyogyszerkutato Intézet KFT

  公开号：EP1216237A2

  公开（公告）日：2002-06-26
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF SARCOIDOSIS
  申请人：INSMED INCORPORATED

  公开号：US20170050945A1

  公开（公告）日：2017-02-23

  Compounds, methods, compositions and kits for treating a patient with pulmonary sarcoidosis are provided. The compositions are formulated for delivery to a patient in need of treatment via inhalation. In one embodiment, the method of treating pulmonary sarcoidosis in a patient in need thereof includes administering to the lungs of the patient via inhalation, a composition comprising an effective amount of a disease-modifying antisarcoid compound, a prodrug thereof, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable inhalation excipient. The disease-modifying antisarcoid compound can be an immunomodulating agent, for example derivatives of mycophenolic acid, or a TNF-α antagonist.
• [EN] PROCESS FOR THE PREPARATION OF MYCOPHENOLIC ACID AND DERIVATIVES THEREOF<br/>[FR] ELABORATION D'ACIDE MYCOPHENOLIQUE ET DE DERIVES DE CET ACIDE
  申请人：GYOGYSZERKUTATO INTEZET

  公开号：WO2001021607A2

  公开（公告）日：2001-03-29

  The invention relates to a microbiological process for the preparation of compounds of general formula (I), wherein R1 means methyl or hydroxymethyl group and R2 stands for hydroxyl or amino group, which comprises growing a Penicillium waksmani fungal strain able to biosynthesising mycophenolic acid on a culture medium containing assimilable carbon and nitrogen sources as well as mineral salts at 22°C to 30°C, separating the compound of general formula (I), wherein R1 means methyl group and R2 stands for hydroxyl group, from the fermentation broth and, if desired, purifying it and, if desired, bioconverting it a) by using the cultures of Streptomyces griseoruber No. 1/6 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms as Streptomyces sp. No. 1/6 under No. NCAIM (P)B 001275 to prepare a compound of general formula (I), wherein R1 means methyl group and R2 stands for amino group; or b) by using the cultures of Streptomyces resistomycificus No. 1/28 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms under No. NCAIM (P)B 001276 to prepare a compound of general formula (I), wherein R1 means hydroxymethyl group and R2 stands for amino group on a culture medium containing assimilable carbon and nitrogen sources as well as mineral salts under submerged, aerated conditions up to completion of the bioconversion, then separating the compound of general formula (I) formed from the culture and, if desired, purifying it.