1-[(3R,4S)-1-[2-(4-ethoxyphenyl)-1,3-benzoxazol-4-yl]-4-hydroxypentan-3-yl]imidazole-4-carboxamide;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[(3R,4S)-1-[2-(4-ethoxyphenyl)-1,3-benzoxazol-4-yl]-4-hydroxypentan-3-yl]imidazole-4-carboxamide;hydrochloride
• 化学式: C24H27ClN4O4
• 分子量: 470.9
• InChiKey: BSQWCZLGOLDMGF-ICCPGPOKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] IMIDAZOLE 4-CARBOXAMIDE COMPOUNDS WITH ADENOSINE DEAMINASE INHIBITING ACTIVITY<br/>[FR] COMPOSES D'IMIDAZOLE 4-CARBOXAMIDE A ACTIVITE D'INHIBITION DE L'ADENOSINE DEAMINASE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2003068768A1

  公开（公告）日：2003-08-21

  Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is 0 or S; and - A - is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

  公式（I）所表示的具有腺苷脱氨酶抑制活性的咪唑化合物：其中R1是可选择取代的芳基或可选择取代的杂环芳基，R2是较低的烷基；R3是羟基或保护羟基；X是0或S；- A - 是较低的烷基，其前药或其盐。这些化合物可用于治疗和/或预防腺苷对其有效的疾病。
• Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity
  申请人：Tsujji Kiyoshi

  公开号：US20050159462A1

  公开（公告）日：2005-07-21

  Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R 1 is optionally substituted aryl or optionally substituted heteroaryl, R 2 is lower alkyl; R 3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

  具有腺苷脱氨酶抑制活性的咪唑化合物的化学式（I）表示为：其中R1是可选取代的芳基或可选取代的杂环基，R2是较低的烷基；R3是羟基或保护羟基；X为O或S；而-A-为较低的烷基烯，其前药或其盐。这些化合物可用于治疗和/或预防腺苷在其中有效的疾病。
• IMIDAZOLE 4-CARBOXAMIDE COMPOUNDS WITH ADENOSINE DEAMINASE INHIBITING ACTIVITY
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1474421A1

  公开（公告）日：2004-11-10
• US7317107B2
  申请人：——

  公开号：US7317107B2

  公开（公告）日：2008-01-08