(E)-3-[2-[(E)-3-(3-methyl-2-phenylmethoxyphenyl)prop-1-enyl]phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-3-[2-[(E)-3-(3-methyl-2-phenylmethoxyphenyl)prop-1-enyl]phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide
• 化学式: C₃₀H₂₇NO₄S₂
• 分子量: 529.7
• InChiKey: ABOBFQVGWRLTQV-BEQXBXOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Prostaglandin receptor ligands
  申请人：Merck Frosst Canada & Co.

  公开号：US20010031766A1

  公开（公告）日：2001-10-18

  Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar 1 —W—Ar 2 —X—Q  II The compounds of the invention are structurally different from NSAIDs and opiates, and are antagonists of the pain and inflammatory effects of E-type prostaglandins.

  本发明揭示了用于治疗前列腺素介导的疾病的化合物和方法，以及某些制药组合物。该化合物由公式II表示：Ar1-W-Ar2-X-Q，本发明的化合物在结构上不同于NSAIDs和鸦片类药物，并且是E型前列腺素疼痛和炎症效应的拮抗剂。
• PROSTAGLANDIN RECEPTOR LIGANDS
  申请人：Merck Frosst Canada & Co.

  公开号：EP1119542A1

  公开（公告）日：2001-08-01
• US6211197B1
  申请人：——

  公开号：US6211197B1

  公开（公告）日：2001-04-03
• [EN] PROSTAGLANDIN RECEPTOR LIGANDS<br/>[FR] LIGANDS DES RECEPTEURS DES PROSTAGLANDINES
  申请人：MERCK FROSST CANADA INC

  公开号：WO2000020371A1

  公开（公告）日：2000-04-13

  Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula (II): Ar1-W-Ar2-X-Q. The compounds of the invention are structurally different from NSAIDs and opiates, and are antagonists of the pain and inflammatory effects of E-type prostaglandins.