4-N-(furan-2-ylmethyl)-4-N,5-dimethyl-2-N-[4-(1,3-oxazol-5-yl)phenyl]pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-N-(furan-2-ylmethyl)-4-N,5-dimethyl-2-N-[4-(1,3-oxazol-5-yl)phenyl]pyrimidine-2,4-diamine
• 化学式: C₂₀H₁₉N₅O₂
• 分子量: 361.4
• InChiKey: MPUSVNLZLRZBKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  80.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] OXAZOLYL-PHENYL-2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS<br/>[FR] COMPOSES D'OXAZOLYL-PHENYL-2,4-DIAMINO-PYRIMIDINE, ET METHODES DE TRAITEMENT DE TROUBLES HYPERPROLIFERATIFS
  申请人：BAYER AG

  公开号：WO2003040141A1

  公开（公告）日：2003-05-15

  Disclosed are oxazolyl-phenyl-2,4-diamino-pyrimidine compounds and derivatives thereof having the formula (I) or (II): wherein A is oxazolyl which is optionally substituted by halogen, linear or branched C1-C5 alkyl and R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as described in the specification. Also disclosed are methods of making the oxazolyl-phenyl-2,4-diamino-pyrimidine compounds. The compounds are S-phase elevated kinase (SPEK) inhibitors and are useful in the treatment of hyperproliferative diseases.