(NE)-N-[[1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-yl]methylidene]hydroxylamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: (NE)-N-[[1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-yl]methylidene]hydroxylamine
• 化学式: C₁₅H₁₂FNO₂
• 分子量: 257.26
• InChiKey: JWISEDYLQRKVHL-CAOOACKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Production methods of citalopram and intermediates therefor
  申请人：Ikemoto Tetsuya

  公开号：US20050080278A1

  公开（公告）日：2005-04-14

  The present invention provides a production method of citalopram and intermediates therefor.

  本发明提供了西酞普兰及其中间体的生产方法。
• Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
  申请人：——

  公开号：US20010056194A1

  公开（公告）日：2001-12-27

  The present invention provides a production method of a 5-phthalancarbonitrile compound, which comprises the use of a novel compound of the formula [I] 1 wherein X is chlorine atom, bromine atom or iodine atom, as a key intermediate. The method of the present invention imposes small environmental burden (without use of a reagent imposing great burden on the environment, such as heavy metal, metal cyanide, thionyl chloride and the like) and is safe. The inventive method is based on a completely new strategy which is different from conventional production methods of 5-phthalancarbonitrile compound.

  本发明提供了一种5-邻苯二腈化合物的生产方法，该方法采用了一种新型化合物[I]1作为关键中间体，其中X为氯原子、溴原子或碘原子。本发明的方法对环境造成的负担较小（不使用对环境造成巨大负担的试剂，如重金属、金属氰化物、亚硫酰氯等），且安全性高。本发明的方法基于一种全新的策略，与5-邻苯二腈化合物的传统生产方法不同。
• Production methods of 5-phthalancarbonitrile compound and an intermediate therefor
  申请人：Sumika Fine Chemicals Co., Ltd.

  公开号：US20020151728A1

  公开（公告）日：2002-10-17

  The present invention provides a production method of a 5-phthalancarbonitrile compound, which comprises the use of a novel compound of the formula [I] 1 wherein X is chlorine atom, bromine atom or iodine atom, as a key intermediate. The method of the present invention imposes small environmental burden (without use of a reagent imposing great burden on the environment, such as heavy metal, metal cyanide, thionyl chloride and the like) and is safe. The inventive method is based on a completely new strategy which is different from conventional production methods of 5-phthalancarbonitrile compound.

  本发明提供了一种五苯并碳腈化合物的生产方法，其包括使用式子[I]中X为氯原子、溴原子或碘原子的新型化合物作为关键中间体。本发明的方法对环境的负担较小（不使用对环境造成很大负担的试剂，如重金属、金属氰化物、亚硫酰氯等），且安全。本发明的方法基于一种完全不同于传统五苯并碳腈化合物生产方法的新策略。
• US6310222B1
  申请人：——

  公开号：US6310222B1

  公开（公告）日：2001-10-30
• US6395910B2
  申请人：——

  公开号：US6395910B2

  公开（公告）日：2002-05-28