(+/-)-3-Acetyl-1-(4-amino-3-methylphenyl)-4,5-dihydro-8-chloro-4-methyl-3H-2,3-benzodiazepine | 439143-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (+/-)-3-Acetyl-1-(4-amino-3-methylphenyl)-4,5-dihydro-8-chloro-4-methyl-3H-2,3-benzodiazepine
• 英文别名: 1-[1-(4-amino-3-methylphenyl)-8-chloro-4-methyl-4,5-dihydro-2,3-benzodiazepin-3-yl]ethanone
• CAS: 439143-67-6
• 化学式: C₁₉H₂₀ClN₃O
• 分子量: 341.84
• InChiKey: VYZRISBRPQIFAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  58.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (+/-)-3-acetyl-4,5-dihydro-8-chloro-4-methyl-1-(3-methyl4-nitrophenyl)-3H-2,3-benzodiazepine 在 aluminum nickel 一水合肼 作用下， 以 甲醇 、 正己烷 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 生成 (+/-)-3-Acetyl-1-(4-amino-3-methylphenyl)-4,5-dihydro-8-chloro-4-methyl-3H-2,3-benzodiazepine
  参考文献：
  名称：

  US2004/92510

  摘要：

  公开号：

文献信息

• [EN] NOVEL 2,3-BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT<br/>[FR] NOUVEAUX DERIVES DE 2,3-BENZODIAZEPINE ET COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITS DERIVES COMME MATIERE ACTIVE
  申请人：EGYT GYOGYSZERVEGYESZETI GYAR

  公开号：WO2002050044A1

  公开（公告）日：2002-06-27

  The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds have antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C1-4 alkyl group or a group of the formula -NR1R2, wherein R?1 and R2¿ represent, independently, a hydrogen atom, a C¿1-4? alkyl group, a C1-4 alkoxy group or a C?3-6¿ cycloalkyl group.

  该发明涉及一种新型2,3-苯并二氮平衍生物，其化学式为(I)，以及含有其作为活性成分的制药组合物。这种新型化合物具有抗痉挛、肌肉松弛和神经保护活性。在式(I)中，X代表氢原子、氯原子或甲氧基；Y代表氢原子或卤原子；Z代表甲基或氯原子；R是C1-4烷基或公式-NR1R2的基团，其中R?1和R2¿独立地表示氢原子、C1-4烷基、C1-4烷氧基或C?3-6?环烷基。
• Novel 2, 3 - benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient
  申请人：——

  公开号：US20040092510A1

  公开（公告）日：2004-05-13

  The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C 1-4 alkyl group or a group of the formula —NR 1 R 2 , wherein R 1 and R 2 represent, independently, a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkoxy group or a C 3-6 cycloalkyl group. 1

  该发明涉及新型2,3-苯二氮平衍生物(I)及含有其作为活性成分的药物组合物。新型化合物具有抗痉挛、肌肉松弛和神经保护活性。在公式I中，X代表氢原子、氯原子或甲氧基；Y代表氢原子或卤原子；Z代表甲基或氯原子；R是C1-4烷基或者是公式-NR1R2的基团，其中R1和R2独立地代表氢原子、C1-4烷基、C1-4烷氧基或C3-6环烷基。
• OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS
  申请人：Ling Istvan

  公开号：US20090233913A1

  公开（公告）日：2009-09-17

  The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties.

  本发明涉及高对映纯度的二氢-2,3-苯并二氮平化合物，其通式为(I)，其中在二氢-2,3-苯并二氮平化合物的4位含有不对称中心，以及其制备方法和用作中间体。这些化合物具有抗惊厥、肌肉松弛和神经保护作用，因为它们具有非竞争性AMPA拮抗作用。
• 2, 3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient
  申请人：Egis Gyogyszergyar RT.

  公开号：US07189711B2

  公开（公告）日：2007-03-13

  The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C1-4 alkyl group or a group of the formula —NR1R2, wherein R1 and R2 represent, independently, a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group or a C3-6 cycloalkyl group.

  本发明涉及公式（I）的新型2,3-苯并二氮平衍生物和含有其作为活性成分的药物组合物。新化合物具有抗痉挛、肌肉松弛和神经保护活性。在公式I中，X代表氢原子、氯原子或甲氧基；Y代表氢原子或卤原子；Z代表甲基或氯原子；R是C1-4烷基或公式-NR1R2的基团，其中R1和R2独立地表示氢原子、C1-4烷基、C1-4烷氧基或C3-6环烷基。
• NOVEL 2,3-BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：Egis Gyogyszergyar Rt.

  公开号：EP1351942B1

  公开（公告）日：2004-07-21