staplabin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: staplabin
• 英文别名: 5-[2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyrano[2,3-e]isoindol-8-yl]pentanoic acid
• 化学式: C₂₈H₃₉NO₆
• 分子量: 485.621
• InChiKey: PREWWCBUIKRUIM-YBFXNURJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  staplabin 、 碘甲烷 在 dimethyl sulfoxide; deprotonated form 作用下， 以 二甲基亚砜 为溶剂， 反应 17.0h， 以7.5 mg的产率得到5-[2-((E)-4,8-Dimethyl-nona-3,7-dienyl)-3,5-dimethoxy-2-methyl-7-oxo-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]isoindol-8-yl]-pentanoic acid methyl ester
  参考文献：
  名称：

  Staplabin, a Novel Fungal Triprenyl Phenol which Stimulates the Binding of Plasminogen to Fibrin and U937 Cell.

  摘要：

  A novel triprenyl phenol, designated staplabin, has been isolated from a culture of Stachybotrys microspora IFO 30018 by solvent extraction and successive chromatographic fractionation using silica gel, Sephadex LH-20 and silica ODS columns. By a combination of spectroscopic analyses, the structure of staplabin is proposed to be 5-(2-(5, 7-dihydroxy-8-methyl-8-(4, 8-dimethyl-3, 7-nonadienyl)-3-oxo-7, 8-dihydro-6H-pyrano[2, 3-e][1, 3]dihydroisoindolyl)pentanoic acid. Staplabin stimulated the binding of plasminogen, the zymogen of the fibrinolytic serine protease plasmin, to both fibrin and U937 cells. Binding was elevated 2-fold at a concentration of 0.3-0.5mM.

  DOI：

  10.7164/antibiotics.49.961

文献信息

• Drug and Method of Treating or Preventing Renal Disease Using Drug
  申请人：Showa University

  公开号：US20210000794A1

  公开（公告）日：2021-01-07

  A drug for renal disease, the drug including a compound represented by the following Formula (I) as an active ingredient.
• DRUG AND METHOD FOR TREATING OR PREVENTING COMPLICATIONS FROM DIABETES, USING SAID DRUG
  申请人：TMS Co., Ltd.

  公开号：US20220218664A1

  公开（公告）日：2022-07-14

  A drug containing a compound represented by formula (I) as an active ingredient, used for complications from diabetes.