5-decyl-2-methyl-1H-imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-decyl-2-methyl-1H-imidazole
• 化学式: C₁₄H₂₆N₂
• 分子量: 222.37
• InChiKey: XUQSWMKJWABTEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Isolation of nucleic acids
  申请人：——

  公开号：US20010018513A1

  公开（公告）日：2001-08-30

  A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing.

  一种从生物材料（如血液）中提取核酸的方法，包括将混合物与具有正电荷的材料接触，以结合负电荷的核酸，然后在材料具有中性或负电荷的pH下洗脱核酸。可以在温和碱性条件下去除核酸，以维持核酸的完整性，并允许在与存储或分析测试立即兼容的试剂中检索核酸。
• [EN] IONIC LIQUIDS CONTAINING SECONDARY HYDROXYL-GROUPS AND A METHOD FOR THEIR PREPARATION<br/>[FR] LIQUIDES IONIQUES CONTENANT DES GROUPES HYDROXYLES SECONDAIRES, ET LEUR METHODE DE PREPARATION
  申请人：UNIV ALABAMA

  公开号：WO2005026179A1

  公开（公告）日：2005-03-24

  The invention provides ionic liquids having a secondary hydroxyl group, and an atom-efficient method for the preparation of these ionic liquids, by epoxidation of a protonated nitrogen- containing organic base (which can optionally be prepared in situ) in the presence of an anion suitable for supporting ionic liquid formation.

  本发明提供了具有次级羟基的离子液体，以及一种原子效率高的方法，用于制备这些离子液体，方法是在适合支持离子液体形成的阴离子存在下，通过氧化剂使质子化的含氮有机碱（可选地在原位制备）发生环氧化反应。
• [EN] MATERIALS AND METHODS RELATING TO POLYIONS AND SUBSTANCE DELIVERY<br/>[FR] MATERIAUX ET PROCEDES RELATIFS AUX POLYIONS ET A L'APPORT DE SUBSTANCES
  申请人：DNA RES INNOVATIONS LTD

  公开号：WO2003101494A1

  公开（公告）日：2003-12-11

  Materials and method are disclose for delivering a desired substance to a target site, using a layered carrier in which the carrier and the substance together form at least three layers which associate by ionic interaction at the first pH, where at least one layer comprises a charge switch material which comprises an ionisable group and which has a positive charge at a first pH and a charge which is less positive, neutral or negative at a second pH, at least one layer comprises a polyionic polymer which is negatively charged at the first pH and at least one layer comprises the desired substance. Preferred carriers are based on the charge switch material poly Bis-Tris and the polyionic polymer polyacrylic acid.

  本发明披露了一种使用分层载体将所需物质输送到目标位点的方法和材料，其中载体和物质共同形成至少三层，这些层在第一个pH值下通过离子交互作用结合在一起，其中至少一层包含一种电荷开关材料，该材料包含可离子化基团，在第一个pH值下具有正电荷，在第二个pH值下具有较少的正电荷、中性或负电荷，至少一层包含负电荷的多离子聚合物，至少一层包含所需物质。首选载体基于电荷开关材料聚合物Bis-Tris和多离子聚合物聚丙烯酸。
• Isolation of nucleid acids
  申请人：DNA Research Innovations Limited

  公开号：EP1473299A2

  公开（公告）日：2004-11-03

  The present invention relates to materials for extracting nucleic acid using charge switch methods which involve, at a first pH, bringing the sample into contact with a material which comprises an ionisable group, wherein the material has a positive charge at said first pH, such that nucleic acid is bound to the material; and releasing the nucleic acid at a second, higher, pH at which the charge on the material is negative, neutral or less positive. The release of the nucleic acid occurs under mild conditions and the ionisable group is provided by a biological buffer, a polyhydroxylated amine, a detergent or surfactant, a carbohydrate, a nucleic acid base, a heterocyclic nitrogen-containing compound, a monoamine, a biological dye, or a negatively ionisable group, the pKa of which is between about 3.0 and 7.0 and a metal oxide which is positively charged at said first pH, and optionally also at said second pH.

  本发明涉及使用电荷转移方法提取核酸的材料，该方法包括在第一 pH 值下，使样品与包含可电离基团的材料接触，其中该材料在所述第一 pH 值下带正电荷，从而使核酸与该材料结合；在第二较高的 pH 值下释放核酸，其中该材料上的电荷为负电荷、中性电荷或较小的正电荷。核酸的释放是在温和的条件下进行的，可电离基团由生物缓冲剂、多羟胺、洗涤剂或表面活性剂、碳水化合物、核酸碱、杂环含氮化合物、单胺、生物染料或可电离的负基（其 pKa 值在 3.0 和 7.0 之间）以及金属氧化物提供，金属氧化物在所述第一 pH 值时带正电，在所述第二 pH 值时也可选择带正电。
• Separation of nucleic acid
  申请人：Baker J. Matthew

  公开号：US20060024712A1

  公开（公告）日：2006-02-02

  Compositions, methods and kits for separating nucleic acid from cell samples. Cells are lysed and nuclear material is flocculated/precipitated. Genomic DNA can be collected from the precipitate and purified. RNA present in the supernatant can be collected (e.g., bound to a solid phase) and purified.

  从细胞样本中分离核酸的组合物、方法和试剂盒。细胞裂解，核物质絮凝/沉淀。可从沉淀物中收集基因组 DNA 并进行纯化。上清液中的 RNA 可以收集（例如，与固相结合）和纯化。