(+)-EGCG-amide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (+)-EGCG-amide
• 英文别名: (+)-[2S,3S]-N-[5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-chroman-3-yl]-3,4,5-trihydroxybenzamide；N-[(2S,3S)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl]-3,4,5-trihydroxybenzamide
• 化学式: C₂₂H₁₉NO₁₀
• 分子量: 457.394
• InChiKey: ILYDGAUVCSMAAP-QKVFXAPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  200
• 氢给体数：
  9
• 氢受体数：
  10

文献信息

• Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use
  申请人：DOU Q. Ping

  公开号：US20120029067A1

  公开（公告）日：2012-02-02

  The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

  本发明涉及合成的绿茶多酚类化合物，它们的合成方式以及它们在抑制蛋白酶体活性和治疗癌症方面的应用。本发明还涉及制药组合物，用于抑制蛋白酶体和治疗癌症的方法。
• Polyphenol proteasome inhibitors, synthesis, and methods of use
  申请人：Dou Q. Ping

  公开号：US20100173985A1

  公开（公告）日：2010-07-08

  The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

  本发明涉及合成的绿茶多酚化合物、它们的合成方式以及它们在抑制蛋白酶体活性和治疗癌症方面的应用。本发明还涉及制药组合物，用于抑制蛋白酶体和治疗癌症的方法。
• POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US20140045931A1

  公开（公告）日：2014-02-13

  The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

  本发明涉及合成绿茶多酚化合物及其合成方式，以及它们在抑制蛋白酶体活性和治疗癌症方面的应用。本发明还涉及制备药物组合物，用于抑制蛋白酶体和治疗癌症的方法。
• US7358383B2
  申请人：——

  公开号：US7358383B2

  公开（公告）日：2008-04-15
• US7767711B2
  申请人：——

  公开号：US7767711B2

  公开（公告）日：2010-08-03