2-[2-Chloro-4-(dimethylamino)phenyl]-8-[2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-5,7-dimethoxychromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-[2-Chloro-4-(dimethylamino)phenyl]-8-[2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-5,7-dimethoxychromen-4-one
• 化学式: C₂₅H₂₉ClN₂O₅
• 分子量: 473.0
• InChiKey: XLFDMLSQFBLVRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• FLAVONE DERIVATIVES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES
  申请人：Nicholas Piramal India Limited

  公开号：EP1556375A2

  公开（公告）日：2005-07-27
• [EN] INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE<br/>[FR] INHIBITEURS DE KINASES DEPENDANTES DES CYCLINES ET LEUR UTILISATION
  申请人：NICHOLAS PIRAMAL INDIA LTD

  公开号：WO2004004632A2

  公开（公告）日：2004-01-15

  The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of such compounds, methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, use of such compounds in the treatment and prophylaxis of diseases, and to the use of the compounds in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing such compounds either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing such compounds of either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.