3-(2,5-dimethylphenyl)-N-propyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2,5-dimethylphenyl)-N-propyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
• 化学式: C₁₇H₂₂N₄O
• 分子量: 298.388
• InChiKey: QYQJKHHYKODCFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  61
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] BICYCLO-PYRAZOLES ACTIFS INHIBITEURS DE KINASE, PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CEUX-CI
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2004013144A1

  公开（公告）日：2004-02-12

  The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrrolo-pyrazole or pyrazolo-azepine. The invention also provides specific pyrrolo-pyrazoles and pyrazolo-azepines, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.

  本发明提供了一种治疗由改变的蛋白激酶活性引起和/或与之相关的疾病的方法，包括向需要治疗的哺乳动物中注射有效量的吡咯-吡唑或吡唑-氮杂七元环。本发明还提供了特定的吡咯-吡唑和吡唑-氮杂七元环，有用的中间体，包含至少两种中间体的库，制备它们的方法以及含有它们的制药组合物，这些组合物有助于治疗由改变的蛋白激酶活性引起和/或与之相关的疾病，如癌症，细胞增殖性疾病，病毒感染，自身免疫性疾病和神经退行性疾病。
• BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1527074A1

  公开（公告）日：2005-05-04