4-[3-Ethyl-5-(4-methylphenyl)pyrazol-1-yl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[3-Ethyl-5-(4-methylphenyl)pyrazol-1-yl]benzenesulfonamide
• 化学式: C₁₈H₁₉N₃O₂S
• 分子量: 341.4
• InChiKey: NMPYQYICQSHCMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2
  申请人：Marnett Lawrence J.

  公开号：US20130052138A1

  公开（公告）日：2013-02-28

  The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.

  目前披露的主题提供了选择性结合环氧合酶-2并包含治疗和/或诊断部分的组合物。还提供了使用所披露的组合物进行诊断（即通过成像）靶细胞和/或治疗与环氧合酶-2生物活性相关的疾病的方法。
• Calcium-activated K channel activator
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1400243A1

  公开（公告）日：2004-03-24

  There is disclosed the use of a compound of formula (I): or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prophylaxis or treatment of a disorder or disease responsive to opening of the large conductance calcium-activated K channel.

  本发明公开了式(I)化合物或其药学上可接受的盐的用途： 或其药学上可接受的盐，用于制造预防或治疗对大电导钙激活 K 通道开放有反应的紊乱或疾病的药物。
• Large conductance calcium-activated K channel opener
  申请人：Kono Rikako

  公开号：US20050075359A1

  公开（公告）日：2005-04-07

  There is disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein R 1 is aminosulfonyl, alkylsulfonyl, etc., R 2 is hydrogen or halogen, R 3 and R 4 are hydrogen, halogen, alkyl or alkoxy, Ring A is benzene, pyridine, etc., and Ring Q is pyrazol, isoxazol, etc., and Ring Q and Ring A may be combined to each other to form a fused ring of the formula: where X is S or O, R 5 is halogen, alkyl, etc., and R 3 and R 4 are the same as mentioned above, or a pharmaceutically acceptable salt thereof as an active ingredient.

  本发明公开了一种由式（I）化合物组成的大电导钙激活 K 通道开通剂： 其中 R 1 是氨基磺酰基、烷基磺酰基等，R 2 是氢或卤素，R 3 和 R 4 是氢、卤素、烷基或烷氧基，环 A 是苯、吡啶等，环 Q 是吡唑、异噁唑等、 环 Q 和环 A 可相互结合形成式中的融合环： 其中 X 为 S 或 O，R 5 是卤素、烷基等，R 3 和 R 4 与上述相同、 或其药学上可接受的盐作为活性成分。
• COX-2-TARGETING, PLATINUM-CONTAINING CONJUGATES AND THEIR USE IN THE TREATMENT OF TUMORS AND CANCERS
  申请人：Reiley Pharmaceuticals, Inc.

  公开号：US20160200752A1

  公开（公告）日：2016-07-14

  The present disclosure provides platinum-containing conjugates that selectively target and kill tumor/cancer cells. The conjugates contain a moiety that selectively targets COX-2, which is overexpressed by a broad range of tumor/cancer cells.
• US8865130B2
  申请人：——

  公开号：US8865130B2

  公开（公告）日：2014-10-21