1,2,13,14-十四烷四醇 | 85866-10-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 1,2,13,14-十四烷四醇
• 英文名称: tetradecane-1,2,13,14-tetrol
• CAS: 85866-10-0
• 化学式: C₁₄H₃₀O₄
• 分子量: 262.39
• InChiKey: SHSYIUNPNAKBKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,2:13,14-二环氧十四烷 在 (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II) 、 水 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以44%的产率得到(S)-12-((R)-oxiran-2-yl)dodecane-1,2-diol
  参考文献：
  名称：

  Hydrolytic and Aminolytic Kinetic Resolution of Terminal Bis-Epoxides

  摘要：

  Hydrolytic and aminolytic kinetic resolution of terminal bis-epoxides catalyzed by (salen)Co-III complexes affords epoxy-diols and N-protected epoxy-amino alcohols with excellent enantio- and diastereoselectivity and good yields. An operationally simple procedure gives instant access to valuable building blocks containing two remote stereocenters in highly enantioenriched form.

  DOI：

  10.1021/jo3024335

文献信息

• use of polyanions to inhibit the cytotoxic activity of histones in the treatment of sepsis.
  申请人：The Australian National University

  公开号：EP2646037B1

  公开（公告）日：2019-01-09
• HISTONE INHIBITION
  申请人：The Australian National University

  公开号：EP2646037A1

  公开（公告）日：2013-10-09
• US9226939B2
  申请人：——

  公开号：US9226939B2

  公开（公告）日：2016-01-05
• [EN] HISTONE INHIBITION<br/>[FR] INHIBITION D'HISTONES
  申请人：UNIV AUSTRALIAN

  公开号：WO2012071611A1

  公开（公告）日：2012-06-07

  The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.
• Hydrolytic and Aminolytic Kinetic Resolution of Terminal Bis-Epoxides
  作者：Jevgenia Bredihhina、Piret Villo、Ka̅rlis Andersons、Lauri Toom、Lauri Vares

  DOI：10.1021/jo3024335

  日期：2013.3.15

  Hydrolytic and aminolytic kinetic resolution of terminal bis-epoxides catalyzed by (salen)Co-III complexes affords epoxy-diols and N-protected epoxy-amino alcohols with excellent enantio- and diastereoselectivity and good yields. An operationally simple procedure gives instant access to valuable building blocks containing two remote stereocenters in highly enantioenriched form.