1,2,3,4-四氢吡咯并[3,2,1-jk][1,4]苯并二氮杂卓 | 27158-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 中文名称: 1,2,3,4-四氢吡咯并[3,2,1-jk][1,4]苯并二氮杂卓
• 英文名称: 4,5,6,7,-Tetrahydropyrrolo<3,2,1,-jk><1,4>benzodiazepin
• 英文别名: Pyrrolo(3,2,1-jk)(1,4)benzodiazepine, 1,2,3,4-tetrahydro-；1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene
• CAS: 27158-93-6
• 化学式: C₁₁H₁₂N₂
• mdl: MFCD01687094
• 分子量: 172.23
• InChiKey: SCHWVSIGGZUEGI-UHFFFAOYSA-N

物化性质

• 沸点：
  354.9±30.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  17
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III
  申请人：Frequency Therapeutics, Inc.

  公开号：US10016507B2

  公开（公告）日：2018-07-10

  The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

  本发明涉及诱导干/祖支持细胞自我更新的组合物和方法，包括诱导干/祖细胞增殖，同时保持子细胞分化成毛细胞的能力。
• Thermoreversible compositions for administration of therapeutic agents
  申请人：Frequency Therapeutics, Inc.

  公开号：US11160868B2

  公开（公告）日：2021-11-02

  The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

  本发明涉及诱导干/祖支持细胞自我更新的组合物和方法，包括诱导干/祖细胞增殖，同时保持子细胞分化成毛细胞的能力。
• THERMOREVERSIBLE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS
  申请人：Frequency Therapeutics, Inc.

  公开号：US20170252448A1

  公开（公告）日：2017-09-07

  The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
• SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: III
  申请人：Frequency Therapeutics, Inc.

  公开号：US20170252449A1

  公开（公告）日：2017-09-07

  The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
• METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING 1,2,3,4-TETRAHYDRO-[1,4]DIAZEPINO[6,7, 1-HI]INDOLYL BASED COMPOUNDS
  申请人：Frequency Therapeutics, Inc.

  公开号：US20170252353A1

  公开（公告）日：2017-09-07

  The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 1,2,3,4-tetrahydro-[1,4]diazepino[6,7, 1-hi]indole moiety having a Formula I and pharmaceutically acceptable salts thereof.