2'-amino-7'-methyl-2-oxospiro[1H-indole-3,4'-5,6-dihydropyrano[2,3-b]pyrrole]-3'-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2'-amino-7'-methyl-2-oxospiro[1H-indole-3,4'-5,6-dihydropyrano[2,3-b]pyrrole]-3'-carbonitrile
• 化学式: C₁₆H₁₄N₄O₂
• 分子量: 294.313
• InChiKey: OISXOPWLUDGVCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-甲基吡咯烷酮 、 2-(2-氧杂环丁-3-亚基)丙二腈 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 0.05h， 以54.4%的产率得到2'-amino-7'-methyl-2-oxospiro[1H-indole-3,4'-5,6-dihydropyrano[2,3-b]pyrrole]-3'-carbonitrile
  参考文献：
  名称：

  An Efficient Procedure for the Synthesis of Spiro (3H-Indole-3,4′ (1′H)pyrano[2,3-C]pyrrole]-5′-carbonitriles Using Solid Inorganic Supports and Microwave Activation

  摘要：

  Microwave irradiation accelerates the Michael condensation of 3-dicyanomethylene-2H-indole-2-one with 2-pyrrolidone/N-methyl-2-pyrrolidone (i) adsorbed on neutral alumina in "dry media" (ii) using absolute ethanol as energy transfer medium. 3-Dicyanomethylene-2H-indol-2-one was synthesized under microwave irradiation using indole-2,3-dione and malononitrile. The results were compared with those obtained following the classical method. The advantages obtained by the use of microwave irradiation are demonstrated.

  DOI：

  10.1080/00397919908086235

文献信息

• An Efficient Procedure for the Synthesis of Spiro (3H-Indole-3,4′ (1′H)pyrano[2,3-C]pyrrole]-5′-carbonitriles Using Solid Inorganic Supports and Microwave Activation
  作者：Anshu Dandia、Harshita Taneja、Rajive Gupta、Satya Paul

  DOI：10.1080/00397919908086235

  日期：1999.7

  Microwave irradiation accelerates the Michael condensation of 3-dicyanomethylene-2H-indole-2-one with 2-pyrrolidone/N-methyl-2-pyrrolidone (i) adsorbed on neutral alumina in "dry media" (ii) using absolute ethanol as energy transfer medium. 3-Dicyanomethylene-2H-indol-2-one was synthesized under microwave irradiation using indole-2,3-dione and malononitrile. The results were compared with those obtained following the classical method. The advantages obtained by the use of microwave irradiation are demonstrated.