1,2-二氢-1,5-二甲基-2-苯基-3H-吡唑-3-酮单氢碘酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1,2-二氢-1,5-二甲基-2-苯基-3H-吡唑-3-酮单氢碘酸盐
• 英文名称: 1,5-dimethyl-2-phenylpyrazol-3-one;hydron;iodide
• 化学式: C11H13IN2O
• 分子量: 316.14
• InChiKey: OUILJQAXEZLLBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  23.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Reagents for the determination of cerebral regional acetylcholinesterase activity
  申请人：DAIICHI PURE CHEMICALS CO., LTD

  公开号：US20020127180A1

  公开（公告）日：2002-09-12

  The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); 1 wherein R 1 represents optionally fluorinated lower alkyl; R 2 represents lower alkyl; and R 3 represents alkenyl substituted at the 1-position with hydroxy, lower alkoxy, lower alkoxyalkyloxy, lower alkoxyalkyloxyalkyloxy, or lower alkanoyloxy and substituted at the end with radioactive iodine, or alkenyloxymethyl substituted at the end with a radioactive iodine reagent containing the same for assaying central local AchE activity; a method for assaying the central local AchE activity; and labeled precursors of the above compounds. After easily passing through the blood-brain barrier, these compounds are hydrolyzed specifically by AchE in the brain into alcohols, which are then captured by the brain. In contrast, alcohols formed outside the brain do not migrate into the brain. The compounds of the invention emit &ggr;-rays at an appropriate energy level. These characteristics make the compounds highly useful as tracers for SPECT in assaying the central AchE activity.

  本发明涉及由通式（1）或（2）表示的N-烷基哌啶衍生物；其中R1表示可选的氟化较低烷基；R2表示较低烷基；R3表示在1位被羟基，较低烷氧基，较低烷氧烷氧基，较低烷氧烷氧烷氧烷基或较低烷酰氧基取代的烯基，并在末端用放射性碘取代，或在末端用含有放射性碘试剂的烯氧甲基取代，用于测定中央局部AchE活性的方法；以及上述化合物的标记前体。这些化合物易于通过血脑屏障，特异性地被脑内AchE水解成醇，然后被大脑捕获。相比之下，在大脑外形成的醇不会迁移到大脑中。本发明的化合物以适当的能量水平发射γ射线，这些特性使得这些化合物在测定中央AchE活性的SPECT示踪剂中非常有用。
• REAGENTS FOR ASSAYING CENTRAL LOCAL ACETYLCHOLINESTERASE ACTIVITY
  申请人：DAIICHI PURE CHEMICALS CO. LTD.

  公开号：EP0989120A1

  公开（公告）日：2000-03-29

  The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); wherein R1 represents optionally fluorinated lower alkyl; R2 represents lower alkyl; and R3 represents alkenyl substituted at the 1-position with hydroxy, lower alkoxy, lower alkoxyalkyloxy, lower alkoxyalkyloxyalkyloxy, or lower alkanoyloxy and substituted at the end with radioactive iodine, or alkenyloxymethyl substituted at the end with a radioactive iodine reagent containing the same for assaying central local AchE activity; a method for assaying the central local AchE activity; and labeled precursors of the above compounds. After easily passing through the blood-brain barrier, these compounds are hydrolyzed specifically by AchE in the brain into alcohols, which are then captured by the brain. In contrast, alcohols formed outside the brain do not migrate into the brain. The compounds of the invention emit γ-rays at an appropriate energy level. These characteristics make the compounds highly useful as tracers for SPECT in assaying the central AchE activity.

  本发明涉及通式（1）或（2）所代表的 N-烷基哌啶衍生物； 其中 R1 代表任选氟化的低级烷基；R2 代表低级烷基；R3 代表在 1 位被羟基、低级烷氧基、低级烷氧基烷氧基、低级烷氧基烷氧基或低级烷酰氧基取代并在末端被放射性碘取代的烯基，或在末端被含有相同的放射性碘试剂取代的烯氧基甲基，用于测定中枢局部 AchE 活性；测定中枢局部 AchE 活性的方法；以及上述化合物的标记前体。这些化合物在轻松通过血脑屏障后，会被大脑中的 AchE 特异性水解为醇，然后被大脑捕获。相反，在脑外形成的醇类不会迁移到脑内。本发明的化合物能以适当的能量水平发射γ射线。这些特性使得本发明化合物在用作 SPECT 检测中枢 AchE 活性的示踪剂时非常有用。
• US6306882B1
  申请人：——

  公开号：US6306882B1

  公开（公告）日：2001-10-23
• US6509003B2
  申请人：——

  公开号：US6509003B2

  公开（公告）日：2003-01-21